Methylamino-PEG4-Boc

• CAT Number: I016096
• CAS Number: 1621616-14-5
• Molecular Formula: C16H33NO6
• Molecular Weight: 335.44
• Purity: ≥95%
• Synonyms: tert-butyl 3-[2-[2-[2-[2-(methylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
• InChI: InChI=1S/C16H33NO6/c1-16(2,3)23-15(18)5-7-19-9-11-21-13-14-22-12-10-20-8-6-17-4/h17H,5-14H2,1-4H3
• InChIKey: ZNZXARLRHZPMJU-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)CCOCCOCCOCCOCCNC

Methylamino-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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