Methyldiiodoarsine

• CAT Number: R054927
• CAS Number: 7207-97-8
• Molecular Formula: CH3AsI2
• Molecular Weight: 343.766
• Purity: ≥95%
• Synonyms: Diiodomethylarsine; Methylarsine Diiodide; Methylarsonous diiodide
• Storage: Store at RT
• IUPAC Name: diiodo(methyl)arsane
• InChI: InChI=1S/CH3AsI2/c1-2(3)4/h1H3
• InChIKey: ZKGSUVMABCXPKK-UHFFFAOYSA-N
• SMILES: C[As](I)I

Methyldiiodoarsine (CAS 7207-97-8) is an arsenite metabolite in wild type CHO cells and in cells deficient in excision repair cross-complementing 1 and 2. Methyldiiodoarsine is an inhibitor of Thioredoxin reductase, an enzyme involved in the response of the cell to oxidative stress. Methyldiiodoarsine is a highly toxic compound.

Reference

1.Lin, Shan, William R. Cullen, and David J. Thomas. "Methylarsenicals and arsinothiols are potent inhibitors of mouse liver thioredoxin reductase." Chemical research in toxicology 12.10 (1999): 924-930.
2.Vahidnia, A., et al. "Comparative toxicity of arsenite metabolites in wild type cho cells and in cells deficient in excision repair cross-complementing 1 and 2." Toxicology in Vitro 22.6 (2008): 1662-1665.