Methyldopate HCl

• CAT Number: I014468
• CAS Number: 2508-79-4
• Molecular Formula: C12H18ClNO4
• Molecular Weight: 275.72
• Purity: ≥95%
• Synonyms: Methyldopate hydrochloride; Aldomet Ester hydrochloride; Aldomet; Methyldopa ethyl ester hydrochloride; Methyldopate HCl; EINECS 219-720-3;;ethyl (S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate hydrochloride
• Target: Neuronal Signaling
• Solubility: Soluble in DMSO
• IUPAC Name: ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate;hydrochloride
• InChI: InChI=1S/C12H17NO4.ClH/c1-3-17-11(16)12(2,13)7-8-4-5-9(14)10(15)6-8;/h4-6,14-15H,3,7,13H2,1-2H3;1H/t12-;/m0./s1
• InChIKey: QSRVZCCJDKYRRF-YDALLXLXSA-N
• SMILES: CCOC(=O)[C@](C)(CC1=CC(=C(C=C1)O)O)N.Cl

Methyldopate hydrochloride（Cat No.:I014468）is a derivative of methyldopa, an antihypertensive medication. It is primarily used in clinical settings as a vasodilator, helping to lower blood pressure by stimulating alpha-2 adrenergic receptors in the brain, which results in reduced sympathetic nervous system activity and vasodilation. This compound is often used in the treatment of hypertension, particularly in conditions where other antihypertensive drugs may not be effective. Methyldopate hydrochloride is also utilized in medical research to study adrenergic pathways and central nervous system regulation of blood pressure. Side effects may include drowsiness, dizziness, and hypotension.

Reference

1: Sousa e Silva JP, Lobo JS, Bonifácio MJ, Machado R, Falcão A, Soares-da-Silva P. In-vivo evaluation of prolonged release bilayer tablets of anti-Parkinson drugs in Göttingen minipigs. J Pharm Pharmacol. 2011 Jun;63(6):780-5. doi: 10.1111/j.2042-7158.2011.01278.x. Epub 2011 Apr 28. PubMed PMID: 21585375.2: Khanmohammadi M, Mobedi E, Garmarudi AB, Mobedi H, Kargosha K. Simultaneous determination of levodopa and carbidopa in levodopa-carbidopa tablets by ATR-FTIR spectrometry. Pharm Dev Technol. 2007;12(6):573-80. PubMed PMID: 18161630.3: Ali SA, Sami MA. Cyclic voltammetric study of alpha-methyldopa at carbon paste electrode. Pak J Pharm Sci. 2005 Jan;18(1):6-17. PubMed PMID: 16431377.4: Ramadan A, El-Massik M, El-Khordagui L, Daabis N, Hammouda Y. Surface treatment: a potential approach for enhancement of solid-state photostability. Int J Pharm. 2006 Jan 13;307(2):141-9. Epub 2005 Nov 9. PubMed PMID: 16289573.5: Okereke CS, Kirby L, Kumar D, Cullen EI, Pratt RD, Hahne WA. Concurrent administration of donepezil HCl and levodopa/carbidopa in patients with Parkinson’s disease: assessment of pharmacokinetic changes and safety following multiple oral doses. Br J Clin Pharmacol. 2004 Nov;58 Suppl 1:41-9. PubMed PMID: 15496222; PubMed Central PMCID: PMC1884553.6: Messiha FS. Neurotoxicological analyses of voluntary alcohol drinking by the rat. Neurobehav Toxicol Teratol. 1985 Mar-Apr;7(2):155-9. PubMed PMID: 3889685.7: Ageel AM, Ginawi OT. Effects of methamphetamine and methyldopa on ethanol induced hypothermia in mice. Jpn J Pharmacol. 1985 Feb;37(2):137-42. PubMed PMID: 3999469.8: Walash MI, Abou Ouf A, Salem FB. Spectrophotometric and titrimetric determination of certain adrenergic drugs, using organic brominating agents. J Assoc Off Anal Chem. 1982 Nov;65(6):1445-51. PubMed PMID: 6757241.9: Reches A, Fahn S. 3-O-methyldopa blocks dopa metabolism in rat corpus striatum. Ann Neurol. 1982 Sep;12(3):267-71. PubMed PMID: 7137962.10: McCrimmon DR, Lalley PM. Inhibition of respiratory neural discharges by clonidine and 5-hydroxytryptophan. J Pharmacol Exp Ther. 1982 Sep;222(3):771-7. PubMed PMID: 6286937.11: Thiede HM, Kehr W. Endogenous dopa in rat brain. Occurrence, distribution and relationship to changes i catecholamine synthesis. Naunyn Schmiedebergs Arch Pharmacol. 1981 Jul;316(4):299-303. PubMed PMID: 6791035.12: Pierach CA, Cardinal R, Bossenmaier I, Watson CJ. Comparison of the Hoesch and the Watson-Schwartz tests for urinary porphobilinogen. Clin Chem. 1977 Sep;23(9):1666-8. PubMed PMID: 890911.