Methyldopate HCl

For research use only. Not for therapeutic Use.

  • CAT Number: I014468
  • CAS Number: 2508-79-4
  • Molecular Formula: C12H18ClNO4
  • Molecular Weight: 275.72
  • Purity: ≥95%
Inquiry Now

Methyldopate HCl si an antihypertensive.


Catalog Number I014468
CAS Number 2508-79-4
Synonyms

Methyldopate hydrochloride; Aldomet Ester hydrochloride; Aldomet; Methyldopa ethyl ester hydrochloride; Methyldopate HCl; EINECS 219-720-3;;ethyl (S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoate hydrochloride

Molecular Formula C12H18ClNO4
Purity ≥95%
Target Neuronal Signaling
Solubility Soluble in DMSO
InChI InChI=1S/C12H17NO4.ClH/c1-3-17-11(16)12(2,13)7-8-4-5-9(14)10(15)6-8;/h4-6,14-15H,3,7,13H2,1-2H3;1H/t12-;/m0./s1
InChIKey QSRVZCCJDKYRRF-YDALLXLXSA-N
SMILES N[C@](CC1=CC=C(O)C(O)=C1)(C)C(OCC)=O.[H]Cl
Reference

</br>1: Sousa e Silva JP, Lobo JS, Bonifácio MJ, Machado R, Falcão A, Soares-da-Silva P. In-vivo evaluation of prolonged release bilayer tablets of anti-Parkinson drugs in Göttingen minipigs. J Pharm Pharmacol. 2011 Jun;63(6):780-5. doi: 10.1111/j.2042-7158.2011.01278.x. Epub 2011 Apr 28. PubMed PMID: 21585375.</br>2: Khanmohammadi M, Mobedi E, Garmarudi AB, Mobedi H, Kargosha K. Simultaneous determination of levodopa and carbidopa in levodopa-carbidopa tablets by ATR-FTIR spectrometry. Pharm Dev Technol. 2007;12(6):573-80. PubMed PMID: 18161630.</br>3: Ali SA, Sami MA. Cyclic voltammetric study of alpha-methyldopa at carbon paste electrode. Pak J Pharm Sci. 2005 Jan;18(1):6-17. PubMed PMID: 16431377.</br>4: Ramadan A, El-Massik M, El-Khordagui L, Daabis N, Hammouda Y. Surface treatment: a potential approach for enhancement of solid-state photostability. Int J Pharm. 2006 Jan 13;307(2):141-9. Epub 2005 Nov 9. PubMed PMID: 16289573.</br>5: Okereke CS, Kirby L, Kumar D, Cullen EI, Pratt RD, Hahne WA. Concurrent administration of donepezil HCl and levodopa/carbidopa in patients with Parkinson’s disease: assessment of pharmacokinetic changes and safety following multiple oral doses. Br J Clin Pharmacol. 2004 Nov;58 Suppl 1:41-9. PubMed PMID: 15496222; PubMed Central PMCID: PMC1884553.</br>6: Messiha FS. Neurotoxicological analyses of voluntary alcohol drinking by the rat. Neurobehav Toxicol Teratol. 1985 Mar-Apr;7(2):155-9. PubMed PMID: 3889685.</br>7: Ageel AM, Ginawi OT. Effects of methamphetamine and methyldopa on ethanol induced hypothermia in mice. Jpn J Pharmacol. 1985 Feb;37(2):137-42. PubMed PMID: 3999469.</br>8: Walash MI, Abou Ouf A, Salem FB. Spectrophotometric and titrimetric determination of certain adrenergic drugs, using organic brominating agents. J Assoc Off Anal Chem. 1982 Nov;65(6):1445-51. PubMed PMID: 6757241.</br>9: Reches A, Fahn S. 3-O-methyldopa blocks dopa metabolism in rat corpus striatum. Ann Neurol. 1982 Sep;12(3):267-71. PubMed PMID: 7137962.</br>10: McCrimmon DR, Lalley PM. Inhibition of respiratory neural discharges by clonidine and 5-hydroxytryptophan. J Pharmacol Exp Ther. 1982 Sep;222(3):771-7. PubMed PMID: 6286937.</br>11: Thiede HM, Kehr W. Endogenous dopa in rat brain. Occurrence, distribution and relationship to changes i catecholamine synthesis. Naunyn Schmiedebergs Arch Pharmacol. 1981 Jul;316(4):299-303. PubMed PMID: 6791035.</br>12: Pierach CA, Cardinal R, Bossenmaier I, Watson CJ. Comparison of the Hoesch and the Watson-Schwartz tests for urinary porphobilinogen. Clin Chem. 1977 Sep;23(9):1666-8. PubMed PMID: 890911. </br> </br>

Request a Quote