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61-73-4-Methylene Blue Methylene Blue

Methylene Blue

For research use only. Not for therapeutic Use.

  • CAT Number: A000087
  • CAS Number: 61-73-4
  • Molecular Formula: C16H18ClN3S
  • Molecular Weight: 319.85
  • Purity: ≥95%
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Methylene Blue（Cat No.:A000087）is a synthetic compound with diverse medical and research applications. It functions as a redox agent, commonly used to treat methemoglobinemia by restoring hemoglobin’s oxygen-carrying capacity. Additionally, it has been studied for its neuroprotective properties and potential in treating cognitive disorders. In microbiology, Methylene Blue serves as a vital dye for staining bacteria and other cells. It also plays a role in photodynamic therapy for cancer. Its wide-ranging effects on cellular processes make it a valuable tool in both clinical treatment and scientific research.


Catalog Number A000087
CAS Number 61-73-4
Synonyms

Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015

Molecular Formula C16H18ClN3S
Purity ≥95%
Storage Store at -20°C
IUPAC Name [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride
InChI InChI=1S/C16H18N3S.ClH/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13;/h5-10H,1-4H3;1H/q+1;/p-1
InChIKey CXKWCBBOMKCUKX-UHFFFAOYSA-M
SMILES CN(C)C1=CC2=C(C=C1)N=C3C=CC(=[N+](C)C)C=C3S2.[Cl-]
Reference

1: Nemezio MA, de Souza Farias SS, Borsatto MC, Aires CP, Corona SAM. Effect of
methylene blue-induced photodynamic therapy on a Streptococcus mutans biofilm
model. Photodiagnosis Photodyn Ther. 2017 Oct 31. pii: S1572-1000(17)30291-0.
doi: 10.1016/j.pdpdt.2017.10.025. [Epub ahead of print] PubMed PMID: 29101088.
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2: Manji F, Wierstra B, Posadas J. Severe Undifferentiated Vasoplegic Shock
Refractory to Vasoactive Agents Treated with Methylene Blue. Case Rep Crit Care.
2017;2017:8747326. doi: 10.1155/2017/8747326. Epub 2017 Oct 2. PubMed PMID:
29098094; PubMed Central PMCID: PMC5642875.
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3: Müller Ramalho K, Ribeiro Cunha S, Mayer-Santos E, de Paula Eduardo C, de
Freitas PM, Cecilia Correa Aranha A, Moura-Netto C. In vitro evaluation of
methylene blue removal from root canal after photodynamic therapy. Photodiagnosis
Photodyn Ther. 2017 Oct 30. pii: S1572-1000(17)30378-2. doi:
10.1016/j.pdpdt.2017.10.024. [Epub ahead of print] PubMed PMID: 29097290.
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4: Tang Z, He J, Chen J, Niu Y, Zhao Y, Zhang Y, Yu C. A sensitive sandwich-type
immunosensor for the detection of galectin-3 based on N-GNRs-Fe-MOFs@AuNPs
nanocomposites and a novel AuPt-methylene blue nanorod. Biosens Bioelectron. 2017
Oct 16;101:253-259. doi: 10.1016/j.bios.2017.10.026. [Epub ahead of print] PubMed
PMID: 29096363.
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5: Tong L, Wang Z, Xia C, Yang Y, Yuan S, Sun D, Xin X. Self-Assembly of
Peptide-Polyoxometalate Hybrid Sub-micrometer Spheres for Photocatalytic
Degradation of Methylene Blue. J Phys Chem B. 2017 Nov 2. doi:
10.1021/acs.jpcb.7b07100. [Epub ahead of print] PubMed PMID: 29095615.
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6: Booth AT, Melmer PD, Tribble B, Mehaffey JH, Tribble C. Methylene Blue for
Vasoplegic Syndrome. Heart Surg Forum. 2017 Oct 31;20(5):E234-E238. doi:
10.1532/hsf.1806. PubMed PMID: 29087290.
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7: Park JA, Yang B, Lee J, Kim IG, Kim JH, Choi JW, Park HD, Nah IW, Lee SH.
Ultrasonic spray pyrolysis synthesis of reduced graphene oxide/anatase TiO(2)
composite and its application in the photocatalytic degradation of methylene blue
in water. Chemosphere. 2017 Oct 17;191:738-746. doi:
10.1016/j.chemosphere.2017.10.094. [Epub ahead of print] PubMed PMID: 29078195.
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8: Wang J, Meng X, Yuan Z, Tian Y, Bai Y, Jin Z. Acrylated Composite Hydrogel
Preparation and Adsorption Kinetics of Methylene Blue. Molecules. 2017 Oct
26;22(11). pii: E1824. doi: 10.3390/molecules22111824. PubMed PMID: 29072617.

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9: Kirby GC, Macano CAW, Nyasavajjala SM, Sahloul M, Nijjar R, Daskalakis M,
Richardson M, Singhal R. The Birmingham experience of high-pressure methylene
blue dye test during primary and revisional bariatric surgery: A retrospective
cohort study. Ann Med Surg (Lond). 2017 Sep 28;23:32-34. doi:
10.1016/j.amsu.2017.09.015. eCollection 2017 Nov. PubMed PMID: 29071067; PubMed
Central PMCID: PMC5651492.
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10: Wang G, Liu X, Wang S, Ge N, Guo J, Sun S. Saline with methylene
blue-assisted endoscopic ultrasound-guided gastrojejunostomy using a
double-flared fully covered metal stent. Endoscopy. 2017 Oct 25. doi:
10.1055/s-0043-119981. [Epub ahead of print] PubMed PMID: 29069704.

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