For research use only. Not for therapeutic Use.
Methylprednisolone is a synthetic glucocorticoid or corticosteroid drug. Common uses include arthritis therapy and short-term treatment of bronchial inflammation or acute bronchitis due to various respiratory diseases. It is used both in the treatment of acute periods and long-term management of autoimmune diseases, most notably systemic lupus erythematosus. It is also used as a treatment for multiple sclerosis. It is on the WHO Model List of Essential Medicines.
| Catalog Number | A001179 |
| CAS Number | 83-43-2 |
| Synonyms | NSC-19987 |
| Molecular Formula | C22H30O5 |
| Purity | ≥95% |
| Target | Glucocorticoid Receptor |
| Solubility | >15.4mg/mL in DMSO |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C22H30O5/c1-12-8-14-15-5-7-22(27,18(26)11-23)21(15,3)10-17(25)19(14)20(2)6-4-13(24)9-16(12)20/h4,6,9,12,14-15,17,19,23,25,27H,5,7-8,10-11H2,1-3H3/t12-,14-,15-,17-,19+,20-,21-,22-/m0/s1 |
| InChIKey | VHRSUDSXCMQTMA-PJHHCJLFSA-N |
| SMILES | O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1 |
| Reference | </br>1:Methylprednisolone pulse therapy and intravenous cyclophosphamide therapy combined with cocktail therapy in severe pediatric Henoch-Schönlein purpura nephritis patient. Kanai H, Kobayashi A, Matsushita K, Sawanobori E, Sugita K, Higashida K.CEN Case Rep. 2013 May;2(1):117-122. doi: 10.1007/s13730-012-0056-8. Epub 2013 Jan 12. PMID: 28509230 Free PMC Article</br>2:High-dose prednisolone after intravenous methylprednisolone improves prognosis of acute exacerbation in idiopathic interstitial pneumonias. Arai T, Tachibana K, Sugimoto C, Inoue Y, Tokura S, Okuma T, Akira M, Kitaichi M, Hayashi S, Inoue Y.Respirology. 2017 May 15. doi: 10.1111/resp.13065. [Epub ahead of print] PMID: 28508494 </br>3:An open, multicenter, randomized clinical study in patients with bullous pemphigoid comparing methylprednisolone and azathioprine with methylprednisolone and dapsone. Sticherling M, Franke A, Aberer E, Gläser R, Hertl M, Pfeiffer C, Rzany B, Schneider S, Shimanovich I, Werfel T, Wilczek A, Zillikens D, Schmidt E.Br J Dermatol. 2017 May 11. doi: 10.1111/bjd.15649. [Epub ahead of print] PMID: 28494097 </br>4:Short-Term Outcome of Intravenous Methylprednisolone Pulse Therapy in Patients With Infantile Spasms. Yeh HR, Kim MJ, Ko TS, Yum MS, You SJ.Pediatr Neurol. 2017 Mar 31. pii: S0887-8994(17)30179-0. doi: 10.1016/j.pediatrneurol.2017.03.017. [Epub ahead of print] PMID: 28483397 </br>5:Adrenocorticotropic hormone <i>versus</i> methylprednisolone added to interferon β in patients with multiple sclerosis experiencing breakthrough disease: a randomized, rater-blinded trial. Berkovich R, Bakshi R, Amezcua L, Axtell RC, Cen SY, Tauhid S, Neema M, Steinman L.Ther Adv Neurol Disord. 2017 Jan;10(1):3-17. doi: 10.1177/1756285616670060. Epub 2016 Oct 19. PMID: 28450891 Free PMC Article</br>6:Methylprednisolone liver toxicity: A new case and a French regional pharmacovigilance survey. Dumortier J, Cottin J, Lavie C, Guillaud O, Hervieu V, Chambon-Augoyard C, Scoazec JY, Vukusic S, Vial T.Clin Res Hepatol Gastroenterol. 2017 Apr 21. pii: S2210-7401(17)30087-6. doi: 10.1016/j.clinre.2017.03.008. [Epub ahead of print] PMID: 28438569 </br>7:Successful treatment of pemphigus foliaceus in a Berrichon du Cher ram with methylprednisolone acetate. Lambacher B, Schoiswohl J, Brunthaler R, Wittek T, Krametter-Frötscher R.Vet Dermatol. 2017 Apr 4. doi: 10.1111/vde.12442. [Epub ahead of print] PMID: 28378419 </br>8:Methylprednisolone Therapy in Acute Traumatic Spinal Cord Injury: Analysis of a Regional Spinal Cord Model Systems Database. Sunshine JE, Dagal A, Burns SP, Bransford RJ, Zhang F, Newman SF, Nair BG, Sharar SR.Anesth Analg. 2017 Apr;124(4):1200-1205. doi: 10.1213/ANE.0000000000001906. PMID: 28319547 </br>9:Early Methylprednisolone Treatment Can Stabilize the Blood-Optic Nerve Barrier in a Rat Model of Anterior Ischemic Optic Neuropathy (rAION). Huang TL, Wen YT, Chang CH, Chang SW, Lin KH, Tsai RK.Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1628-1636. doi: 10.1167/iovs.16-21017. PMID: 28297028 </br>10:Intratympanic methylprednisolone perfusion as a salvage treatment for profound idiopathic sudden sensorineural hearing loss. Dai Y, Lu L, Hou J, Yang X, Li H, Yang Y, She W.J Laryngol Otol. 2017 May;131(5):404-410. doi: 10.1017/S0022215117000548. Epub 2017 Mar 14. PMID: 28290919 |
