For research use only. Not for therapeutic Use.
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks[1].
Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks[1].
Methylproamine can protect bystander cells from radiation-induced DNA damage[2].
Methylproamine has a concentration-dependent radioprotective effect[3]
| Catalog Number | I002428 |
| CAS Number | 188247-01-0 |
| Synonyms | N,N,3-trimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline |
| Molecular Formula | C28H31N7 |
| Purity | ≥95% |
| InChI | InChI=1S/C28H31N7/c1-18-15-20(33(2)3)6-8-22(18)28-30-23-9-5-19(16-25(23)32-28)27-29-24-10-7-21(17-26(24)31-27)35-13-11-34(4)12-14-35/h5-10,15-17H,11-14H2,1-4H3,(H,29,31)(H,30,32) |
| InChIKey | ADKLMOJIJGHCCD-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)N(C)C)C2=NC3=C(N2)C=C(C=C3)C4=NC5=C(N4)C=C(C=C5)N6CCN(CC6)C |
| Reference | [1]. Carl N Sprung, et al. Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. [2]. Susanne Burdak-Rothkamm, et al. Radioprotection of targeted and bystander cells by methylproamine. Strahlenther Onkol. 2015 Mar;191(3):248-55. [3]. Pavel N Lobachevsky, et al. Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87(3):274-83. [4]. Lobachevsky PN, Vasireddy RS, Broadhurst S, Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87(3):274-83. [5]. Sprung CN, Vasireddy RS, Karagiannis TC, Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. Mutat Res. 2010 Oct 13;692(1-2):49-52. [6]. Martin RF, Broadhurst S, Reum ME, In vitro studies with methylproamine: a potent new radioprotector. Cancer Res. 2004 Feb 1;64(3):1067-70. |
