Methyltetrazine-amido-PEG5-alkyne

• CAT Number: I016541
• CAS Number: 2322322-23-4
• Molecular Formula: C₂₄H₃₃N₅O₆
• Molecular Weight: 487.55
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: N-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methyl]-3-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]propanamide
• InChI: 1S/C24H33N5O6/c1-3-9-31-11-13-33-15-17-35-18-16-34-14-12-32-10-8-23(30)25-19-21-4-6-22(7-5-21)24-28-26-20(2)27-29-24/h1,4-7H,8-19H2,2H3,(H,25,30)
• InChIKey: OHZFOEAHYKQSRL-UHFFFAOYSA-N
• SMILES: CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCOCCOCCOCC#C

Methyltetrazine-amido-PEG5-alkyne (Cat No.: I016541) is a bioorthogonal reagent designed for click chemistry applications in bioconjugation and molecular labeling. Featuring a methyltetrazine moiety and an alkyne functional group linked by a PEG5 spacer, it enables rapid and selective reactions with trans-cyclooctene (TCO) and azide-functionalized molecules. This versatile linker enhances solubility and minimizes steric hindrance, making it ideal for biomolecular modifications, drug delivery research, and imaging studies. Its stability and efficiency ensure precise conjugation in chemical biology, proteomics, and targeted therapeutic applications.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562