Methyltetrazine-PEG4-maleimide

• CAT Number: I016539
• CAS Number: 1802908-02-6
• Molecular Formula: C₂₄H₃₀N₆O₇
• Molecular Weight: 514.53
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 3-(2,5-dioxopyrrol-1-yl)-N-[2-[2-[2-[2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenoxy]ethoxy]ethoxy]ethoxy]ethyl]propanamide
• InChI: InChI=1S/C24H30N6O7/c1-18-26-28-24(29-27-18)19-2-4-20(5-3-19)37-17-16-36-15-14-35-13-12-34-11-9-25-21(31)8-10-30-22(32)6-7-23(30)33/h2-7H,8-17H2,1H3,(H,25,31)
• InChIKey: DPEUPJJPNNSKGW-UHFFFAOYSA-N
• SMILES: CC1=NN=C(N=N1)C2=CC=C(C=C2)OCCOCCOCCOCCNC(=O)CCN3C(=O)C=CC3=O

Methyltetrazine-PEG4-maleimide（Cat No.:I016539）is a compound used in bioconjugation and targeted drug delivery research. It consists of a methyltetrazine group, a polyethylene glycol (PEG) linker (PEG4), and a maleimide group. The maleimide group reacts specifically with thiol groups (-SH) on cysteine residues in proteins or antibodies, allowing for stable conjugation. The PEG4 linker enhances solubility and reduces immune recognition, improving the pharmacokinetics of the conjugate. This compound is used in applications like antibody-drug conjugates (ADCs) for targeted cancer therapy, where it helps deliver cytotoxic agents selectively to tumor cells.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562