For research use only. Not for therapeutic Use.
Methyltetrazine-PEG5-alkyne (Cat No.: I016542) is a multifunctional, bioorthogonal crosslinker used in chemical biology and bioconjugation applications. It features a methyltetrazine group for rapid, selective inverse electron demand Diels–Alder (IEDDA) reactions with trans-cyclooctene (TCO) and an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAC) “click” chemistry. The PEG5 spacer enhances solubility and flexibility, reducing steric hindrance in complex biological systems. Methyltetrazine-PEG5-alkyne is widely used for dual-labeling, targeted drug delivery, and biomolecular imaging, enabling precise and efficient modification of proteins, antibodies, and other biomolecules.
| CAS Number | 1802907-97-6 |
| Molecular Formula | C₂₀H₂₆N₄O₅ |
| Purity | ≥95% |
| Target | PROTAC Linkers |
| IUPAC Name | 3-methyl-6-[4-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]phenyl]-1,2,4,5-tetrazine |
| InChI | 1S/C20H26N4O5/c1-3-8-25-9-10-26-11-12-27-13-14-28-15-16-29-19-6-4-18(5-7-19)20-23-21-17(2)22-24-20/h1,4-7H,8-16H2,2H3 |
| InChIKey | OAKPIEOTVXLRCN-UHFFFAOYSA-N |
| SMILES | CC1=NN=C(N=N1)C2=CC=C(C=C2)OCCOCCOCCOCCOCC#C |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
