Methyltetrazine-PEG5-NHS ester

• CAT Number: I016546
• CAS Number: 1802907-92-1
• Molecular Formula: C₂₄H₃₁N₅O₉
• Molecular Weight: 533.53
• Purity: ≥95%
• Target: PROTAC Linkers

Methyltetrazine-PEG5-NHS ester(CAT: I016546) is a compound used in bioconjugation and labeling applications. It is a derivative of PEG (polyethylene glycol) functionalized with a methyltetrazine group and an NHS (N-hydroxysuccinimide) ester. The NHS ester allows for the reaction with primary amines, commonly found on proteins and peptides, forming stable amide bonds. The methyltetrazine group is highly reactive and can undergo rapid and specific click chemistry reactions with trans-cyclooctene (TCO)-modified molecules. Methyltetrazine-PEG5-NHS ester is commonly used for the site-specific labeling of biomolecules, such as antibodies, peptides, and proteins, enabling the attachment of various probes, dyes, or other molecules for imaging, targeting, or functionalization purposes.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562