Methyltetrazine-Ph-NHS ester

• CAT Number: I016372
• CAS Number: 1644644-96-1
• Molecular Formula: C₁₅H₁₃N₅O₄
• Molecular Weight: 327.29
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 2-[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]acetate
• InChI: InChI=1S/C15H13N5O4/c1-9-16-18-15(19-17-9)11-4-2-10(3-5-11)8-14(23)24-20-12(21)6-7-13(20)22/h2-5H,6-8H2,1H3
• InChIKey: BIHJLZOOHNOUCG-UHFFFAOYSA-N
• SMILES: CC1=NN=C(N=N1)C2=CC=C(C=C2)CC(=O)ON3C(=O)CCC3=O

Methyltetrazine-Ph-NHS ester（Cat No.:I016372）is a chemical compound used in bioorthogonal chemistry, particularly for conjugating biomolecules in targeted drug delivery and imaging applications. The tetrazine group is highly reactive and can undergo a fast, selective reaction with strained alkyne groups in other molecules, facilitating the formation of stable covalent bonds. The NHS ester (N-hydroxysuccinimide ester) allows for the attachment of the compound to amine groups on proteins, peptides, or other molecules. This makes methyltetrazine-Ph-NHS ester useful in developing targeted therapies, diagnostics, and bioimaging agents while minimizing off-target interactions.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562