For research use only. Not for therapeutic Use.
Metiamide（Cat No.:I003274） is a histamine H2-receptor antagonist that was developed as a derivative of the H2 antagonist burimamide. It was specifically designed to improve the pharmacological properties and efficacy of burimamide. Metiamide acts by blocking the H2 receptors, which are involved in regulating gastric acid secretion. By inhibiting these receptors, metiamide reduces the production of stomach acid and is used in the treatment of gastric ulcers and other related conditions.
| Catalog Number | I003274 |
| CAS Number | 34839-70-8 |
| Molecular Formula | C9H16N4S2 |
| Purity | ≥95% |
| Target | H2 receptor |
| Solubility | DMSO：≥ 2.4 mg/mL |
| Storage | Store at -20°C |
| IC50 | 0.92 uM (Ki with glycolaldehyde as the varied substrate for E3) |
| IUPAC Name | 1-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]thiourea |
| InChI | InChI=1S/C9H16N4S2/c1-7-8(13-6-12-7)5-15-4-3-11-9(14)10-2/h6H,3-5H2,1-2H3,(H,12,13)(H2,10,11,14) |
| InChIKey | FPBPLBWLMYGIQR-UHFFFAOYSA-N |
| SMILES | CC1=C(N=CN1)CSCCNC(=S)NC |
| Reference | </br>1:Metiamide–an orally active histamine H2-receptor antagonist. 1973. Black JW, Duncan WA, Emmett JC, Ganellin CR, Hesselbo T, Parsons ME, Wyllie JH.Agents Actions. 1994 Dec;43(3-4):91-5; discussion 96. No abstract available. PMID: 7725982 </br>2:Toxic effects of the histamine H(2) receptor antagonist metiamide on bone-marrow haemopoietic and stromal progenitor cells in vitro. Bird TL, Larkin MM, Betton GR.Toxicol In Vitro. 1988;2(3):221-4. PMID: 20702338 </br>3:Orthogonal arrays of particles in the gastric parietal cell of the rat: differences between superficial and basal cells in the gland and after pentagastrin or metiamide treatment. Bordi C, Amherdt M, Perrelet A.Anat Rec. 1986 May;215(1):28-34. PMID: 3085548 </br>4:Antagonism of hypotensive and bradycardic effects of centrally administered guanfacine by metiamide in anesthetized rabbits. Otorii T, Ohkubo K, Suzuki K.Jpn Heart J. 1985 Jul;26(4):577-84. PMID: 2865383 </br>5:Influence of species and drug pretreatment on the metabolic oxidation of cimetidine and metiamide. Dixon PA, Okereke NO, Ogundahunsi A.Biochem Pharmacol. 1985 Jun 1;34(11):2028-30. No abstract available. PMID: 3924053 </br>6:The effect of intramolecular hydrogen bonding on the thermodynamics of partitioning of an isomer of the histamine H2-receptor antagonist metiamide. Mitchell RC, Dunkley D.J Pharm Pharmacol. 1984 May;36(5):331-2. PMID: 6145771 </br>7:Effects of the anti-inflammatory agents indomethacin, metiamide and acetylsalicylic acid on the induction of hyperplasia in hamster cheek-pouch epithelium and ear epidermis. Harris RR, Mackenzie IC.J Oral Pathol. 1984 Apr;13(2):128-36. PMID: 6425473 </br>8:Effect of histamine H-2 blocker – metiamide – on the isolated atrial preparations of rabbits & guinea pigs. Thomas M, Stephen PM.Indian J Exp Biol. 1983 Feb;21(2):84-7. No abstract available. PMID: 6414949 </br>9:Effect of metiamide, a histamine H2-receptor antagonist on reserpine-induced gastric ulcers and acid secretion. Hano J, Bugajski J, Wantuch C.Pol J Pharmacol Pharm. 1983;35(1):15-27. PMID: 6412220 </br>10:Effects of proglumide and metiamide on vagally stimulated gastric acid secretion in chickens. Nishimura M, Park JH, Nakagawa H, Urakawa N.Nihon Juigaku Zasshi. 1982 Apr;44(2):283-8. No abstract available. PMID: 6810001 |
