For research use only. Not for therapeutic Use.
Metixene (CAT: I007970) is an anticholinergic drug that is used as an antiparkinsonian agent. It belongs to the class of compounds known as antimuscarinic agents, which block the effects of the neurotransmitter acetylcholine in certain parts of the central nervous system. Metixene acts by binding to and inhibiting muscarinic receptors, specifically the M1 subtype, in the brain. This action helps to restore the balance of neurotransmitters and alleviate the symptoms of Parkinson’s disease, such as tremors, rigidity, and bradykinesia. Metixene is often used in combination with other medications for the management of Parkinson’s disease.
| Catalog Number | I007970 |
| CAS Number | 4969-02-2 |
| Synonyms | Metixene, Methixene, Methixart, CholinFall, Tremonil, Trest;1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine |
| Molecular Formula | C20H23NS |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| IUPAC Name | 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine |
| InChI | InChI=1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3 |
| InChIKey | MJFJKKXQDNNUJF-UHFFFAOYSA-N |
| SMILES | CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24 |
| Reference | 1:Med Welt. 1977 Nov 25;28(47):1938-40. [Follow-up studies in the treatment of extrapyramidal tremor forms with metixene].Topaloğlu C, PMID: 607081 |
