For research use only. Not for therapeutic Use.
Metoprolol is a selective β1 receptor blocker medication. It is used to treat high blood pressure, chest pain due to poor blood flow to the heart, and a number of conditions involving an abnormally fast heart rate. It is also used to prevent further heart problems after myocardial infarction and to prevent headaches in those with migraines.
| Catalog Number | I007400 |
| CAS Number | 37350-58-6 |
| Synonyms | Metoprolol, Lopressor, Betaloc, CGP-2175, H 93-26;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol |
| Molecular Formula | C15H25NO3 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol |
| InChI | InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3 |
| InChIKey | IUBSYMUCCVWXPE-UHFFFAOYSA-N |
| SMILES | CC(C)NCC(COC1=CC=C(C=C1)CCOC)O |
| Reference | </br>1:Metoprolol Therapy and <i>CYP2D6</i> Genotype. Dean L.In: Pratt V, McLeod H, Dean L, Malheiro A, Rubinstein W, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012-.2017 Apr 4. PMID: 28520381 Free Books & Documents</br>2:Regio- and stereo-selective oxidation of a cardiovascular drug metoprolol mediated by cytochrome P450 2D and 3A enzymes in marmoset livers. Uehahara S, Ishii S, Uno Y, Inoue T, Sasaki E, Yamazaki H.Drug Metab Dispos. 2017 May 11. pii: dmd.117.075630. doi: 10.1124/dmd.117.075630. [Epub ahead of print] PMID: 28495902 </br>3:Propafenone for supraventricular arrhythmias in septic shock-Comparison to amiodarone and metoprolol. Balik M, Kolnikova I, Maly M, Waldauf P, Tavazzi G, Kristof J.J Crit Care. 2017 Apr 26;41:16-23. doi: 10.1016/j.jcrc.2017.04.027. [Epub ahead of print] PMID: 28463737 </br>4:Metoprolol-pridopidine drug-drug interaction and food effect assessments of pridopidine, a new drug for treatment of Huntington Disease. Rabinovich-Guilatt L, Steiner L, Hallak H, Pastino G, Muglia P, Spiegelstein O.Br J Clin Pharmacol. 2017 Apr 27. doi: 10.1111/bcp.13317. [Epub ahead of print] PMID: 28449367 </br>5:Bisoprolol compared with carvedilol and metoprolol succinate in the treatment of patients with chronic heart failure. Fröhlich H, Torres L, Täger T, Schellberg D, Corletto A, Kazmi S, Goode K, Grundtvig M, Hole T, Katus HA, Cleland JGF, Atar D, Clark AL, Agewall S, Frankenstein L.Clin Res Cardiol. 2017 Apr 22. doi: 10.1007/s00392-017-1115-0. [Epub ahead of print] PMID: 28434020 </br>6:Ivabradine Versus Metoprolol In Patients With Acute Inferior Wall Myocardial Infarction- /’Expanding Arena For Ivabradine/’. Go Khroo RK, Priti K, Ranwa BL, Kishor K, Bisht D, Gupta S.Cardiovasc Ther. 2017 Apr 19. doi: 10.1111/1755-5922.12266. [Epub ahead of print] PMID: 28423233 </br>7:Neutrophil stunning by metoprolol reduces infarct size. García-Prieto J, Villena-Gutiérrez R, Gómez M, Bernardo E, Pun-García A, García-Lunar I, Crainiciuc G, Fernández-Jiménez R, Sreeramkumar V, Bourio-Martínez R, García-Ruiz JM, Del Valle AS, Sanz-Rosa D, Pizarro G, Fernández-Ortiz A, Hidalgo A, Fuster V, Ibanez B.Nat Commun. 2017 Apr 18;8:14780. doi: 10.1038/ncomms14780. PMID: 28416795 Free PMC Article</br>8:Antianginal Efficacy and Tolerability of Ranolazine as an Add-on Drug to Concomitant Medications Primarily Metoprolol in Chronic Stable Angina Patients: A Prospective, Open-Label Study. Khot AM, Anuradha HV, Prakash VS, Shivamurathy MC.J Pharmacol Pharmacother. 2017 Jan-Mar;8(1):21-27. doi: 10.4103/jpp.JPP_168_16. PMID: 28405132 Free PMC Article</br>9:Formulation and evaluation of controlled release ethylcellulose and polyethylene glycol microspheres containing metoprolol tartrate. Malipeddi VR, Awasthi R, Dua K.Interv Med Appl Sci. 2016 Jun 1;8(2):60-67. doi: 10.1556/1646.8.2016.2.6. Review. PMID: 28386461 Free PMC Article</br>10:Chronic exposure to the ß-blocker metoprolol reduces growth and alters gene expression of gonadotropins and vitellogenin in Nile tilapia (Oreochromis niloticus). Gröner F, Höhne C, Kleiner W, Kloas W.Ecotoxicol Environ Saf. 2017 Jul;141:271-279. doi: 10.1016/j.ecoenv.2017.03.032. Epub 2017 Apr 6. PMID: 28359993 |
