Metoprolol Tartrate

For research use only. Not for therapeutic Use.

  • CAT Number: A000490
  • CAS Number: 56392-17-7
  • Molecular Formula: C34H56N2O12
  • Molecular Weight: 684.81
  • Purity: ≥95%
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Metoprolol Tartrate is a selective β1 receptor blocker medication. It is used to treat high blood pressure, chest pain due to poor blood flow to the heart, and a number of conditions involving an abnormally fast heart rate. It is also used to prevent further heart problems after myocardial infarction and to prevent headaches in those with migraines.


Catalog Number A000490
CAS Number 56392-17-7
Synonyms

56392-17-7; 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy)propan-2-ol 2,3-dihydroxysuccinate (2:1); Metoprolol-(+,-) (+)-tartrate salt; Prestwick_1009; AC1O4WIQ; SCHEMBL2051655

Molecular Formula C34H56N2O12
Purity ≥95%
Target Neuronal Signaling
Solubility >32.3mg/mL in DMSO
Storage -20°C
InChI 1S/2C15H25NO3.C4H6O6/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-1(3(7)8)2(6)4(9)10/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2,5-6H,(H,7,8)(H,9,10)
InChIKey YGULWPYYGQCFMP-UHFFFAOYSA-N
SMILES CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.CC(C)NCC(COC1=CC=C(C=C1)CCOC)O.C(C(C(=O)O)O)(C(=O)O)O
Reference

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L, Brandão MAF. Stability of Alprazolam, Atropine Sulfate, Glutamine,
Levofloxacin, Metoprolol Tartrate, Nitrofurantoin, Ondansetron Hydrochloride,
Oxandrolone, Pregabaline, and Riboflavin in SyrSpend SF pH4 Oral Suspensions. Int
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2: Malipeddi VR, Awasthi R, Dua K. Formulation and evaluation of controlled
release ethylcellulose and polyethylene glycol microspheres containing metoprolol
tartrate. Interv Med Appl Sci. 2016 Jun 1;8(2):60-67. doi:
10.1556/1646.8.2016.2.6. Review. PubMed PMID: 28386461; PubMed Central PMCID:
PMC5370352.
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3: Yang Y, Shen L, Li J, Shan WG. Preparation and evaluation of metoprolol
tartrate sustained-release pellets using hot melt extrusion combined with hot
melt coating. Drug Dev Ind Pharm. 2017 Jun;43(6):939-946. doi:
10.1080/03639045.2017.1287715. Epub 2017 Feb 9. PubMed PMID: 28128647.
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Rouleau JL, Tardif JC, Jenna S, Haibe-Kains B, Leduc R, Deblois D. Older adults
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5: Malipeddi VR, Awasthi R, Ghisleni DD, de Souza Braga M, Kikuchi IS, de Jesus
Andreoli Pinto T, Dua K. Preparation and characterization of metoprolol tartrate
containing matrix type transdermal drug delivery system. Drug Deliv Transl Res.
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6: Allam A, Fetih G. Sublingual fast dissolving niosomal films for enhanced
bioavailability and prolonged effect of metoprolol tartrate. Drug Des Devel Ther.
2016 Aug 2;10:2421-33. doi: 10.2147/DDDT.S113775. eCollection 2016. PubMed PMID:
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7: Wang Y, Yang M, Shen R, Shao S, Chen L, Gong W, Shan L, Gao C. Development of
metoprolol tartrate-loaded sustained-release pellets: effect of talc on the
mechanism of drug release. Pharm Dev Technol. 2016 Jul 28:1-10. doi:
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8: Monteyne T, Adriaensens P, Brouckaert D, Remon JP, Vervaet C, De Beer T.
Stearic acid and high molecular weight PEO as matrix for the highly water soluble
metoprolol tartrate in continuous twin-screw melt granulation. Int J Pharm. 2016
Oct 15;512(1):158-167. doi: 10.1016/j.ijpharm.2016.07.035. Epub 2016 Jul 21.
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9: Husain T, Shoaib MH, Yousuf RI, Maboos M, Khan M, Bashir L, Naz S. Formulation
development and comparative in vitro study of metoprolol tartrate (IR) tablets.
Pak J Pharm Sci. 2016 May;29(3):853-60. PubMed PMID: 27166530.
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10: Zhao S, Yu F, Liu N, Di Z, Yan K, Liu Y, Li Y, Zhang H, Yang Y, Yang Z, Li Z,
Mei X. Synchronous delivery of felodipine and metoprolol tartrate using
monolithic osmotic pump technology. Drug Dev Ind Pharm. 2016 Nov;42(11):1723-31.
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