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53734-79-5-Metralindole HCl Metralindole HCl

Metralindole HCl

For research use only. Not for therapeutic Use.

  • CAT Number: I032186
  • CAS Number: 53734-79-5
  • Molecular Formula: C15H18ClN3O
  • Molecular Weight: 291.779
  • Purity: 98%
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Related Small Molecules: GRP78-IN-3     nor-NOHA monoacetate     TGN-020 sodium    

Metralindole is a reversible inhibitor of monoamine oxidase A (RIMA) which was investigated in Russia as a potential antidepressant.[1] It is structurally and pharmacologically related to pirlindole.


Catalog Number I032186
CAS Number 53734-79-5
Synonyms

Metralindole; Inkazan.Incasan,

Molecular Formula C15H18ClN3O
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 1H-3,4,6a-Triazafluoranthene, 2,4,5,6-tetrahydro-9-methoxy-4-methyl-, monohydrochloride
InChI InChI=1S/C15H17N3O.ClH/c1-17-7-8-18-13-4-3-10(19-2)9-12(13)11-5-6-16-15(17)14(11)18;/h3-4,9H,5-8H2,1-2H3;1H
InChIKey RQQVSZWEVNAKGW-UHFFFAOYSA-N
SMILES CN1C2=NCCC3=C2N(C4=C3C=C(OC)C=C4)CC1.[H]Cl
Reference

1: Andreeva NI, Golovina SM, Parshin VA, Mashkovskiĭ MD. [Effects of antidepressive agents on tolerance of hypoxia and physical exercise]. Biull Eksp Biol Med. 1991 Aug;112(8):156-8. Russian. PubMed PMID: 1786375.
2: Andreeva NI. [Comparative pharmacological study of the antidepressants pyrazidol, inkazan, caroxazone and imipramine]. Farmakol Toksikol. 1982 Jul-Aug;45(4):9-13. Russian. PubMed PMID: 6889985.
3: Mashkovskiĭ MD, Andreeva NI, Parshin VA. [Effect of piracetam on the action of antidepressants (experimental data)]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1989;89(2):129-31. Russian. PubMed PMID: 2728714.
4: Mashkovskiĭ MD, Bogdanov MB, Bondarenko NA. [The effect of pyrazidol and inkazan on the rotation behavior of rats]. Farmakol Toksikol. 1989 Nov-Dec;52(6):29-32. Russian. PubMed PMID: 2625142.
5: Kuksgaus NE, Golovina SM, Andreeva NI. [The influence of the Soviet antidepressants pyrazidol and inkazan on the effects of clonidine]. Farmakol Toksikol. 1991 Jan-Feb;54(1):11-4. Russian. PubMed PMID: 1860489.
6: Avdulov NA, Maĭsov NI. [Atypical antidepressants: effect on synaptosomal uptake of serotonin and GABA]. Biull Eksp Biol Med. 1981 Nov;92(11):564-6. Russian. PubMed PMID: 7198493.
7: Mashkovskiĭ MD, Andreeva NI. [Experimental and clinical characteristics of the Soviet antidepressant inkasan]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(3):410-3. Russian. PubMed PMID: 6720183.
8: Liu CC, Lee CL, Chan CC, Tu TC, Liao CC, Wu CH, Chen TK. Maintenance treatment is not necessary after Helicobacter pylori eradication and healing of bleeding peptic ulcer: a 5-year prospective, randomized, controlled study. Arch Intern Med. 2003 Sep 22;163(17):2020-4. PubMed PMID: 14504114.
9: Verstakova OL, Gerchikov LN, Gus’kova TA, Liberman SS, Chicherina LA. [Toxicological study of the Soviet tetracyclic antidepressant inkazan]. Farmakol Toksikol. 1985 Jul-Aug;48(4):99-103. Russian. PubMed PMID: 4043371.
10: Kaminka ME, Kuksgauz NE, Andreeva NI. [The effect of the new Soviet antihistamine and antiserotonin preparation bikarfen on the central nervous system]. Farmakol Toksikol. 1990 Jul-Aug;53(4):21-3. Russian. PubMed PMID: 1977614.
11: Natsvlishvili NA, Samonina GE, Ashmarin IP. [The antiulcer action of antidepressants. II. The effect of the antidepressants inkazan, azafen, and OF-743 in combination with arginine on ethanol-evoked damage to the gastric mucosa in rats]. Nauchnye Doki Vyss Shkoly Biol Nauki. 1991;(7):52-7. Russian. PubMed PMID: 1782273.
12: Squires RF, Saederup E. Clozapine and several other antipsychotic/antidepressant drugs preferentially block the same ‘core’ fraction of GABA(A) receptors. Neurochem Res. 1998 Oct;23(10):1283-90. PubMed PMID: 9804284.
13: Mashkovskiĭ MD, Andreeva NI. [Comparative pharmacological study of a series of new antidepressants]. Farmakol Toksikol. 1981 Nov-Dec;44(6):698-702. Russian. PubMed PMID: 6975726.
14: Gorkin VZ. [Recent advances in studies on the specific inhibition and nature of monoamine oxidases (review)]. Vopr Med Khim. 1982 Mar-Apr;28(2):2-9. Review. Russian. PubMed PMID: 6805132.
15: Andreeva NI, Sharova SA. [Anorexigenic action of a new antidepressant, inkasan, and its effect on basal gastric secretion in rats]. Farmakol Toksikol. 1980 Nov-Dec;43(6):664-7. Russian. PubMed PMID: 7450001.
16: Andreeva NI, Mashkovskii MD. [Pharmacological study of the new Soviet antidepressant, inkazan]. Farmakol Toksikol. 1980 Mar-Apr;43(2):133-7. Review. Russian. PubMed PMID: 7002587.
17: Roshchina LF. [Effect of the new antidepressant, inkazan, on the bioelectrical activity of the brain and conditioned reflexes]. Farmakol Toksikol. 1980 Jul-Aug;43(4):349-52. Russian. PubMed PMID: 7439364.
18: Panasiuk LV, Arefolov VA, Andreeva NI, Raevskiĭ KS, Mashkovskiĭ MD. [Effect of the tetracyclic antidepressants pyrazidol and inkazan on the adrenergic nerve transmission in the rat vas deferens]. Farmakol Toksikol. 1982 Jan-Feb;45(1):13-7. Russian. PubMed PMID: 6276226.
19: Mashkovskiĭ MD, Andreeva NI, Parshin VA. [Influence of antidepressants on benzodiazepine (diazepam and nitrazepam) effects]. Farmakol Toksikol. 1988 Jul-Aug;51(4):16-9. Russian. PubMed PMID: 2903832.
20: Andreeva NI, Golovina SM, Faermark MF, Shvarts GIa, Mashkovskiĭ MD. [The comparative influence of pyrazidol, inkazan and other antidepressant monoamine oxidase inhibitors on the pressor effect of tyramine]. Farmakol Toksikol. 1991 Mar-Apr;54(2):38-40. Russian. PubMed PMID: 1884793.

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