Metronidazole

• CAT Number: A000778
• CAS Number: 443-48-1
• Molecular Formula: C6H9N3O3
• Molecular Weight: 171.20
• Purity: ≥95%
• Synonyms: Anagiardil; Gineflavir; Metronidazol; 2-Methyl-5-nitroimidazole-1-ethanol
• Target: Apoptosis
• Storage: <label class=
• IUPAC Name: 2-(2-methyl-5-nitroimidazol-1-yl)ethanol
• InChI: InChI=1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
• InChIKey: VAOCPAMSLUNLGC-UHFFFAOYSA-N
• SMILES: CC1=NC=C(N1CCO)[N+](=O)[O-]

Metronidazole（Cat No.:A000778）is a widely used antimicrobial agent effective against anaerobic bacteria and certain parasites, making it valuable in treating infections such as bacterial vaginosis, trichomoniasis, and amoebiasis. It works by entering microbial cells and disrupting DNA synthesis, leading to cell death. Metronidazole is available in oral, topical, and intravenous forms, providing versatility in clinical use. Due to its effectiveness in treating anaerobic infections, it is often used in gastrointestinal, dental, and gynecological treatments. Metronidazole’s specific action and well-documented profile make it a cornerstone in antimicrobial therapy and research.

Overview of Clinical Research

Metronidazole is a DNA synthesis inhibitor developed by AbbVIe.

Reference

1: Robbie MO, Sweet RL. Metronidazole use in obstetrics and gynecology: a review. Am J Obstet Gynecol. 1983 Apr 1;145(7):865-81. Review. PubMed PMID: 6340508.
2: Edwards DI. Mechanisms of selective toxicity of metronidazole and other nitroimidazole drugs. Br J Vener Dis. 1980 Oct;56(5):285-90. Review. PubMed PMID: 7000306; PubMed Central PMCID: PMC1045807.
3: Brogden RN, Heel RC, Speight TM, Avery GS. Metronidazole in anaerobic infections: a review of its activity, pharmacokinetics and therapeutic use. Drugs. 1978 Nov;16(5):387-417. Review. PubMed PMID: 363399.
4: Baines EJ. Metronidazole: its past, present and future. J Antimicrob Chemother. 1978 Sep;4 Suppl C:97-111. Review. PubMed PMID: 151090.