Metyrapone

• CAT Number: I003995
• CAS Number: 54-36-4
• Molecular Formula: C14H14N2O
• Molecular Weight: 226.30
• Purity: ≥95%
• Synonyms: 2-methyl-1,2-di(pyridin-3-yl)propan-1-one
• Target: Autophagy
• Solubility: H2O: ≥ 38 mg/mL
• Storage: Store at +4 ℃
• IUPAC Name: 2-methyl-1,2-dipyridin-3-ylpropan-1-one
• InChI: InChI=1S/C14H14N2O/c1-14(2,12-6-4-8-16-10-12)13(17)11-5-3-7-15-9-11/h3-10H,1-2H3
• InChIKey: FJLBFSROUSIWMA-UHFFFAOYSA-N
• SMILES: CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2

Metyrapone（Cat No.:I003995）is a reversible inhibitor of 11β-hydroxylase, an enzyme involved in the final step of cortisol synthesis in the adrenal cortex. By blocking cortisol production, metyrapone is used diagnostically to assess adrenal function and in the treatment of Cushing’s syndrome, where excess cortisol is produced. Metyrapone is also studied for its potential in modulating the hypothalamic-pituitary-adrenal (HPA) axis and has been explored in research related to stress, depression, and PTSD. Its ability to lower cortisol levels makes it a valuable tool in both clinical and research settings.