Mevalonic acid lithium salt

• CAT Number: I046048
• CAS Number: 2618458-93-6
• Molecular Formula: C6H11LiO4
• Molecular Weight: 154.09
• Purity: ≥95%
• Synonyms: lithium;3,5-dihydroxy-3-methylpentanoate
• InChI: InChI=1S/C6H12O4.Li/c1-6(10,2-3-7)4-5(8)9;/h7,10H,2-4H2,1H3,(H,8,9);/q;+1/p-1
• InChIKey: PVWNXFFXFNEHDZ-UHFFFAOYSA-M
• SMILES: [Li+].CC(CCO)(CC(=O)[O-])O

Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure[1][2].
Mevalonic acid lithium salt (80, 90, 100, 110 µM; 72 h) shows prevention of simvastatin-induced loss of viability of C2C12myotube cells in vitro[1].

Reference

[1]. Moschetti A, et al. Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes. Nanomedicine. 2021 Oct;37:102439.
 [Content Brief]

[2]. Soma MR, et al. Cholesterol and mevalonic acid modulation in cell metabolism and multiplication. Toxicol Lett. 1992 Dec;64-65 Spec No:1-15.
 [Content Brief]