Mevastatin

• CAT Number: A000954
• CAS Number: 73573-88-3
• Molecular Formula: C₂₃H₃₄O₅
• Molecular Weight: 390.51
• Purity: ≥95%
• Synonyms: Compactin; 73573-88-3; ML-236B; Mevastatinum; Mevastatina
• Target: HMG-CoA Reductase
• Solubility: >16mg/mL in DMSO
• Storage: Store at -20°C
• IUPAC Name: [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
• InChI: InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
• InChIKey: AJLFOPYRIVGYMJ-INTXDZFKSA-N
• SMILES: CC[C@H](C)C(=O)O[C@H]1CCC=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O

Mevastatin（Cat No.:A000954）is a naturally occurring statin that inhibits HMG-CoA reductase, the enzyme responsible for cholesterol biosynthesis in the liver. By blocking this enzyme, mevastatin effectively reduces cholesterol levels, making it a precursor in the development of modern statins like lovastatin. It was initially discovered from the fungus Penicillium citrinum and has been extensively studied for its lipid-lowering properties. Beyond its cardiovascular applications, mevastatin has shown potential in cancer research due to its ability to interfere with cellular proliferation and induce apoptosis in certain tumor cells.

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