Mexiletine

• CAT Number: I007974
• CAS Number: 31828-71-4
• Molecular Formula: C11H17NO
• Molecular Weight: 179.263
• Purity: ≥95%
• Synonyms: Mexiletine, Mexitil, Mexiletene, KO-1173;1-(2,6-dimethylphenoxy)propan-2-amine
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 1-(2,6-dimethylphenoxy)propan-2-amine
• InChI: InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3
• InChIKey: VLPIATFUUWWMKC-UHFFFAOYSA-N
• SMILES: CC1=C(C(=CC=C1)C)OCC(C)N

Mexiletine (Cat.No:I007974) is a non-selective voltage-gated sodium channel blocker which belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart, or seriously irregular heartbeats. It slows conduction in the heart and makes the heart tissue less sensitive. Mexiletine may also be of use in patients experiencing refractory pain and is also effective for treating muscle stiffness resulting from myotonic dystrophy (Steinert/’s disease) or nondystrophic myotonias such as myotonia congenita (Thomsen disease).

Reference

1:Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation. Liu G, Xue X, Gao C, Huang J, Qi D, Zhang Y, Dong JZ, Ma CS, Yan GX.J Am Heart Assoc. 2017 May 18;6(5). pii: e005482. doi: 10.1161/JAHA.117.005482. PMID: 28522677 2:Surfactant-assisted dispersive liquid-liquid microextraction combined with field-amplified sample stacking in capillary electrophoresis for the determination of mexiletine and lidocaine. Yeh YH, Chen WC, Chang SY.J Sep Sci. 2017 Apr 5. doi: 10.1002/jssc.201700042. [Epub ahead of print] PMID: 28378407 3:The effects of pure potassium channel blocker nifekalant and sodium channel blocker mexiletine on malignant ventricular tachyarrhythmias. Otuki S, Hasegawa K, Watanabe H, Katsuumi G, Yagihara N, Iijima K, Sato A, Izumi D, Furushima H, Chinushi M, Aizawa Y, Minamino T.J Electrocardiol. 2017 May – Jun;50(3):277-281. doi: 10.1016/j.jelectrocard.2016.09.005. Epub 2016 Sep 8. PMID: 28238302 4:Different electrophysiological effects of the levo- and dextrorotatory isomers of mexiletine in isolated rabbit cardiac muscle. Gurabi Z, Patocskai B, Györe B, Virág L, Mátyus P, Papp JG, Varró A, Koncz I.Can J Physiol Pharmacol. 2017 Feb 22. doi: 10.1139/cjpp-2016-0599. [Epub ahead of print] PMID: 28226224 5:Neuromuscular excitability changes produced by sustained voluntary contraction and response to mexiletine in myotonia congenita. Ginanneschi F, Mignarri A, Lucchiari S, Ulzi G, Comi GP, Rossi A, Dotti MT.Neurophysiol Clin. 2017 Jan 30. pii: S0987-7053(16)30358-6. doi: 10.1016/j.neucli.2017.01.003. [Epub ahead of print] PMID: 28153715 6:Did Mutation Type Affect the Efficacy of Mexiletine Observed in Patients With LQTS Type 3? Hameed A.J Am Coll Cardiol. 2017 Jan 17;69(2):248. doi: 10.1016/j.jacc.2016.06.083. No abstract available. PMID: 28081835 7:Reply: Did Mutation Type Affect the Efficacy of Mexiletine Observed in Patients With LQTS Type 3? Mazzanti A, Maragna R, Napolitano C, Priori SG.J Am Coll Cardiol. 2017 Jan 17;69(2):248-249. doi: 10.1016/j.jacc.2016.09.981. No abstract available. PMID: 28081834 8:Infantile Epileptic Encephalopathy Associated With SCN2A Mutation Responsive to Oral Mexiletine. Foster LA, Johnson MR, MacDonald JT, Karachunski PI, Henry TR, Nascene DR, Moran BP, Raymond GV.Pediatr Neurol. 2017 Jan;66:108-111. doi: 10.1016/j.pediatrneurol.2016.10.008. Epub 2016 Oct 18. PMID: 27867041 9:Therapeutic drug monitoring of mexiletine at a large academic medical center. Nei SD, Danelich IM, Lose JM, Leung LY, Asirvatham SJ, McLeod CJ.SAGE Open Med. 2016 Sep 21;4:2050312116670659. eCollection 2016. PMID: 27708780 Free PMC Article10:Amphetamine-positive urine drug screens in the setting of mexiletine use: A case series. Bui QM, Allen LA, Monte AA, Page RL 2nd, McIlvennan CK.J Heart Lung Transplant. 2016 Aug;35(8):1045-8. doi: 10.1016/j.healun.2016.05.004. Epub 2016 May 17. No abstract available. PMID: 27287628