For research use only. Not for therapeutic Use.
Mezlocillin sodium is an extended spectrum β-lactam antibiotic and is sparingly soluble in aqueous solution 0.47 mg/mL.</br>β-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases, however, mezlocillin is resistant to a number of β-lactamases.
| Catalog Number | R006058 |
| CAS Number | 59798-30-0 |
| Molecular Formula | C21H24N5NaO8S2 |
| Purity | ≥95% |
| Storage | 2-8 °C |
| Reference | <p>Guzmán, Flavio, MD. /Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” <em>Medical Pharmacology</em>. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.</p><p>Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.</p></span></p> |
