MFH290

• CAT Number: I032212
• CAS Number: 2088715-91-5
• Molecular Formula: C26H31N5O3S2
• Molecular Weight: 525.69
• Purity: ≥95%
• Synonyms: N-[4-[(3R)-3-[[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]amino]piperidine-1-carbonyl]phenyl]prop-2-enamide
• InChI: InChI=1S/C26H31N5O3S2/c1-5-21(32)29-18-10-8-17(9-11-18)24(33)31-12-6-7-19(15-31)30-25-28-14-23(36-25)35-16-22-27-13-20(34-22)26(2,3)4/h5,8-11,13-14,19H,1,6-7,12,15-16H2,2-4H3,(H,28,30)(H,29,32)/t19-/m1/s1
• InChIKey: COGUZYALRYMQTD-LJQANCHMSA-N
• SMILES: CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC3CCCN(C3)C(=O)C4=CC=C(C=C4)NC(=O)C=C

MFH290 (Cat No.: I032212) is a potent and selective inhibitor of the ERK5 (extracellular signal-regulated kinase 5) pathway, a key component of the MAPK signaling cascade involved in cell proliferation, survival, and inflammation. By targeting ERK5 kinase activity, MFH290 enables researchers to dissect its role in cancer progression, cardiovascular diseases, and immune responses. It supports the development of targeted therapies and offers insights into non-canonical MAPK signaling. MFH290 is intended for research use only in molecular biology and pharmacological studies.

Reference

[1]. Yao Liu, et al. Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13. J Med Chem. 2020 Jul 9;63(13):6708-6726.
[Content Brief]

[2]. Yao Liu, et al. Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13. J Med Chem. 2020 Jul 9;63(13):6708-6726.
[Content Brief]