For research use only. Not for therapeutic Use.
MFZ 10-7 is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5[1]. MFZ 10-7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
MFZ 10-7 has approximately 1150- and 3000-fold lower affinity for MAO-B (monoamine oxidase-B enzyme) and TXA2 (thromboxane A2 receptor), respectively, compared to mGluR5[1].
MFZ 10-7 can lower oral sucrose self-administration rate but has no effect on total sucrose intake[1].
| Catalog Number | I010957 |
| CAS Number | 1224431-15-5 |
| Synonyms | 3-fluoro-5-[2-(6-methylpyridin-2-yl)ethynyl]benzonitrile |
| Molecular Formula | C15H9FN2 |
| Purity | ≥95% |
| InChI | InChI=1S/C15H9FN2/c1-11-3-2-4-15(18-11)6-5-12-7-13(10-17)9-14(16)8-12/h2-4,7-9H,1H3 |
| InChIKey | ZGEXQIMQZVRTDZ-UHFFFAOYSA-N |
| SMILES | CC1=NC(=CC=C1)C#CC2=CC(=CC(=C2)F)C#N |
| Reference | [1]. Keck TM, et al. A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict Biol. |
