MG-277

• CAT Number: I017738
• CAS Number: 2411085-89-5
• Molecular Formula: C₄₁H₄₂Cl₂FN₅O₅
• Molecular Weight: 774.71
• Purity: ≥95%
• Target: Apoptosis
• InChI: 1S/C41H42Cl2FN5O5/c42-24-14-15-28-30(21-24)46-39(54)41(28)33(26-12-8-13-29(43)34(26)44)35(48-40(41)18-4-2-5-19-40)37(52)45-20-6-1-3-9-23-10-7-11-25-27(23)22-49(38(25)53)31-16-17-32(50)47-36(31)51/h7-8,10-15,21,31,33,35,48H,1-6,9,16-20,22H2,(H,45,52)(H,46,54)(H,47,50,51)/t31?,33-,35+,41+/m0/s1
• InChIKey: BANRYGZZIMCKNA-OYGJEQPESA-N
• SMILES: C1CCC2(CC1)[C@@]3([C@H]([C@@H](N2)C(=O)NCCCCCC4=C5CN(C(=O)C5=CC=C4)C6CCC(=O)NC6=O)C7=C(C(=CC=C7)Cl)F)C8=C(C=C(C=C8)Cl)NC3=O

MG-277 (Cat No.: I017738) is a small-molecule inhibitor that targets the 90 kDa ribosomal S6 kinase (RSK), a key downstream effector in the MAPK/ERK signaling pathway. By inhibiting RSK activity, MG-277 interferes with cellular processes such as proliferation, survival, and differentiation, making it valuable in cancer research. It is used to study RSK-related signaling in various malignancies and to evaluate potential therapeutic strategies targeting this pathway. MG-277 serves as a tool compound for elucidating RSK function and its role in disease progression.

Reference

[1]. Yang J, et al. Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. J Med Chem. 2019 Oct 21.