MG 624

• CAT Number: I010396
• CAS Number: 77257-42-2
• Molecular Formula: C22H30NOI
• Molecular Weight: 451.39
• Purity: ≥95%
• Synonyms: N,N,N-Triethyl-2-[4-(2-phenylethenyl)phenoxy]ethanaminium iodide
• Target: Neuronal Signaling
• Solubility: Soluble to 20 mM in DMSO and to 10 mM in ethanol
• Storage: Store at RT
• IUPAC Name: triethyl-[2-[4-[(E)-2-phenylethenyl]phenoxy]ethyl]azanium;iodide
• InChI: InChI=1S/C22H30NO.HI/c1-4-23(5-2,6-3)18-19-24-22-16-14-21(15-17-22)13-12-20-10-8-7-9-11-20;/h7-17H,4-6,18-19H2,1-3H3;1H/q+1;/p-1/b13-12+
• InChIKey: RDTKUZXIHMTSJO-UEIGIMKUSA-M
• SMILES: CC[N+](CC)(CC)CCOC1=CC=C(C=C1)/C=C/C2=CC=CC=C2.[I-]

MG 624（Cat No.:I010396）is a selective antagonist of the metabotropic glutamate receptor 5 (mGluR5), a type of G-protein coupled receptor involved in synaptic plasticity, learning, and various neurological processes. By blocking mGluR5, MG 624 has shown potential in reducing excitatory neurotransmission, which may help in treating neurological and psychiatric conditions such as anxiety, depression, and certain forms of schizophrenia. Additionally, mGluR5 antagonism has been explored for its neuroprotective effects in disorders like Alzheimer’s disease and Parkinson’s disease.