MGAT2-IN-1

• CAT Number: I013226
• CAS Number: 1800025-30-2
• Molecular Formula: C₂₇H₂₁ClF₅N₇O₃S
• Molecular Weight: 654.01
• Purity: ≥95%
• Target: Acyltransferase
• Solubility: DMSO
• IUPAC Name: N-(4-chloro-2,6-difluorophenyl)-1-[5-[2-methyl-5-(trifluoromethyl)pyrazol-3-yl]pyrimidin-2-yl]-7-(2-oxopyrrolidin-1-yl)-2,3-dihydroindole-5-sulfonamide
• InChI: InChI=1S/C27H21ClF5N7O3S/c1-38-20(11-22(36-38)27(31,32)33)15-12-34-26(35-13-15)40-6-4-14-7-17(10-21(25(14)40)39-5-2-3-23(39)41)44(42,43)37-24-18(29)8-16(28)9-19(24)30/h7-13,37H,2-6H2,1H3
• InChIKey: VSZRYLHBOKTNBO-UHFFFAOYSA-N
• SMILES: CN1C(=CC(=N1)C(F)(F)F)C2=CN=C(N=C2)N3CCC4=CC(=CC(=C43)N5CCCC5=O)S(=O)(=O)NC6=C(C=C(C=C6F)Cl)F

MGAT2-IN-1 is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC50 of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.

Reference

[1]. Take K, et al. Pharmacological Inhibition of Monoacylglycerol O-Acyltransferase 2 Improves Hyperlipidemia, Obesity, and Diabetes by Change in Intestinal Fat Utilization. PLoS One. 2016 Mar 3;11(3):e0150976.