For research use only. Not for therapeutic Use.
MGCD-265 analog（Cat No.:I005271）is a multi-targeted kinase inhibitor designed to block key receptors such as MET, VEGFR, and AXL, which are involved in tumor growth, angiogenesis, and metastasis. By inhibiting these pathways, MGCD-265 analog disrupts cancer cell proliferation and survival, making it a promising therapeutic candidate for treating various solid tumors, including lung and gastric cancers. Its ability to target multiple receptors simultaneously offers potential for overcoming drug resistance and improving patient outcomes. MGCD-265 analog is being explored in preclinical and clinical studies to assess its efficacy in cancer therapy.
| Catalog Number | I005271 |
| CAS Number | 875337-44-3 |
| Synonyms | N-[[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]carbamothioyl]-2-phenylacetamide |
| Molecular Formula | C26H20FN5O2S2 |
| Purity | ≥95% |
| Target | Tie-2 |
| Solubility | 10 mM in DMSO |
| Storage | 3 years -20C powder |
| IC50 | 10 nM (VEGFR2), 29 nM(c-Met) |
| IUPAC Name | N-[[3-fluoro-4-[2-(1-methylimidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxyphenyl]carbamothioyl]-2-phenylacetamide |
| InChI | InChI=1S/C26H20FN5O2S2/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)34-21-8-7-17(12-18(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,35) |
| InChIKey | UFICVEHDQUKCEA-UHFFFAOYSA-N |
| SMILES | CN1C=C(N=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=S)NC(=O)CC5=CC=CC=C5)F |
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