MHI-148

• CAT Number: I042560
• CAS Number: 172971-76-5
• Molecular Formula: C42H52BrClN2O4
• Molecular Weight: 764.23
• Purity: ≥95%
• Synonyms: 6-[(2E)-2-[(2E)-2-[3-[(E)-2-[1-(5-carboxypentyl)-3,3-dimethylindol-1-ium-2-yl]ethenyl]-2-chlorocyclohex-2-en-1-ylidene]ethylidene]-3,3-dimethylindol-1-yl]hexanoic acid;bromide
• InChI: InChI=1S/C42H51ClN2O4.BrH/c1-41(2)32-18-9-11-20-34(32)44(28-13-5-7-22-38(46)47)36(41)26-24-30-16-15-17-31(40(30)43)25-27-37-42(3,4)33-19-10-12-21-35(33)45(37)29-14-6-8-23-39(48)49;/h9-12,18-21,24-27H,5-8,13-17,22-23,28-29H2,1-4H3,(H-,46,47,48,49);1H
• InChIKey: SBSLCJXMLMGYFH-UHFFFAOYSA-N
• SMILES: CC1(C2=CC=CC=C2[N+](=C1C=CC3=C(C(=CC=C4C(C5=CC=CC=C5N4CCCCCC(=O)O)(C)C)CCC3)Cl)CCCCCC(=O)O)C.[Br-]

MHI-148 is a near-infrared heptamethine cyanine dye with tumor-targeting properties for cancer detection, diagnosis and research. MHI-148 is immediately taken up and accumulated by lysosomes and mitochondria of tumor cells, but not in lysosomes and mitochondria of normal cells[1].
MHI-148 (10 µM, 1 h) is significantly more absorbed in HT-29 colon carcinoma cells than in normal NIH3T3 fibroblasts and has tumor imaging and targeting properties[1].
MHI-148 (0-1.5 µM, 3 days) causes only negligible toxicity in HT-29 and NIH3T3 cells[1].

Reference

[1]. Athira Raveendran, et al. Heptamethine Cyanine Dye MHI-148-Mediated Drug Delivery System to Enhance the Anticancer Efficiency of Paclitaxel. Int J Nanomedicine. 2021 Oct 21;16:7169-7180.
 [Content Brief]