MHP (CAT: I013631) is an activator of sphingosine kinase 1 (SPHK1), an enzyme involved in the regulation of sphingolipid metabolism. By activating SPHK1, MHP promotes the conversion of sphingosine to sphingosine-1-phosphate (S1P), a bioactive lipid mediator. MHP has been found to have stimulatory effects on cyclic adenosine monophosphate (cAMP) production in keratinocytes (KC), leading to increased mRNA and protein expression of cAMP. This activation of the cAMP pathway may have implications for various cellular processes and signaling pathways.
| Catalog Number | I013631 |
| CAS Number | 1104874-94-3 |
| Molecular Formula | C₁₆H₂₃NO₄ |
| Purity | ≥95% |
| Target | SPHK |
| Solubility | DMSO |
| IUPAC Name | methyl (2S)-2-(hexanoylamino)-3-(4-hydroxyphenyl)propanoate |
| InChI | InChI=1S/C16H23NO4/c1-3-4-5-6-15(19)17-14(16(20)21-2)11-12-7-9-13(18)10-8-12/h7-10,14,18H,3-6,11H2,1-2H3,(H,17,19)/t14-/m0/s1 |
| InChIKey | GBTVWZMJUZJPBU-AWEZNQCLSA-N |
| SMILES | CCCCCC(=O)NC(CC1=CC=C(C=C1)O)C(=O)OC |
| Reference | [1]. Jeong SK, et al. Sphingosine kinase 1 activation enhances epidermal innate immunity through sphingosine-1-phosphate stimulation of cathelicidin production. J Dermatol Sci. 2015 Sep;79(3):229-34. |
