MI-1061

• CAT Number: I018117
• CAS Number: 1410737-34-6
• Molecular Formula: C₃₀H₂₆Cl₂FN₃O₄
• Molecular Weight: 582.45
• Purity: ≥95%
• Target: Metabolic Enzyme/Protease
• InChI: 1S/C30H26Cl2FN3O4/c31-17-9-12-20-22(15-17)35-28(40)30(20)23(19-5-4-6-21(32)24(19)33)25(36-29(30)13-2-1-3-14-29)26(37)34-18-10-7-16(8-11-18)27(38)39/h4-12,15,23,25,36H,1-3,13-14H2,(H,34,37)(H,35,40)(H,38,39)/t23-,25+,30+/m0/s1
• InChIKey: BIDSEXPFIMKDMF-LOLKONATSA-N
• SMILES: C1CCC2(CC1)[C@@]3([C@H]([C@@H](N2)C(=O)NC4=CC=C(C=C4)C(=O)O)C5=C(C(=CC=C5)Cl)F)C6=C(C=C(C=C6)Cl)NC3=O

MI-1061 (Cat.No:I018117) is a small molecule compound that functions as a selective inhibitor of the phosphatidylinositol 3-kinase (PI3K) pathway. It has shown promising anti-cancer activity by blocking the signaling cascade that promotes cell proliferation and survival. MI-1061 is being investigated for its potential use in targeted cancer therapies, and further preclinical and clinical studies are underway to assess its efficacy and safety.

Reference

[1]. Aguilar A, et al. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannichring-opening-cyclization reaction mechanism in spiro-oxindoles. J Med Chem. 2014 Dec 26;57(24):10486-98.