For research use only. Not for therapeutic Use.
MI-136（Cat No.:I002106） is an inhibitor that effectively suppresses the expression of androgen receptor (AR) target genes induced by dihydrotestosterone (DHT). By targeting the androgen receptor, MI-136 can inhibit the activation of downstream genes regulated by AR. This compound shows promise in modulating androgen signaling pathways and may have potential applications in the treatment of androgen receptor-dependent diseases, such as prostate cancer and androgen-related disorders.
| Catalog Number | I002106 |
| CAS Number | 1628316-74-4 |
| Synonyms | 5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile |
| Molecular Formula | C23H21F3N6S |
| Purity | ≥95% |
| Target | Vitamin D Related/Nuclear Receptor |
| Solubility | DMSO: ≥ 31 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1H-indole-2-carbonitrile |
| InChI | InChI=1S/C23H21F3N6S/c24-23(25,26)10-18-9-19-21(28-13-29-22(19)33-18)31-16-3-5-32(6-4-16)12-14-1-2-20-15(7-14)8-17(11-27)30-20/h1-2,7-9,13,16,30H,3-6,10,12H2,(H,28,29,31) |
| InChIKey | PSOJDGBGVBEYJX-UHFFFAOYSA-N |
| SMILES | C1CN(CCC1NC2=C3C=C(SC3=NC=N2)CC(F)(F)F)CC4=CC5=C(C=C4)NC(=C5)C#N |
| Reference | <p style=/line-height:25px/> |
