MI-136

• CAT Number: I002106
• CAS Number: 1628316-74-4
• Molecular Formula: C23H21F3N6S
• Molecular Weight: 470.50
• Purity: ≥95%
• Synonyms: 5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile
• Target: Vitamin D Related/Nuclear Receptor
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: Store at -20°C
• IUPAC Name: 5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1H-indole-2-carbonitrile
• InChI: InChI=1S/C23H21F3N6S/c24-23(25,26)10-18-9-19-21(28-13-29-22(19)33-18)31-16-3-5-32(6-4-16)12-14-1-2-20-15(7-14)8-17(11-27)30-20/h1-2,7-9,13,16,30H,3-6,10,12H2,(H,28,29,31)
• InChIKey: PSOJDGBGVBEYJX-UHFFFAOYSA-N
• SMILES: C1CN(CCC1NC2=C3C=C(SC3=NC=N2)CC(F)(F)F)CC4=CC5=C(C=C4)NC(=C5)C#N

MI-136（Cat No.:I002106） is an inhibitor that effectively suppresses the expression of androgen receptor (AR) target genes induced by dihydrotestosterone (DHT). By targeting the androgen receptor, MI-136 can inhibit the activation of downstream genes regulated by AR. This compound shows promise in modulating androgen signaling pathways and may have potential applications in the treatment of androgen receptor-dependent diseases, such as prostate cancer and androgen-related disorders.

Reference

[1]. Malik R, et al. Targeting the MLL complex in castration-resistant prostate cancer. Nat Med. 2015 Apr;21(4):344-52.