MI 2 MALT1 inhibitor

• CAT Number: I000268
• CAS Number: 1047953-91-2
• Molecular Formula: C19H17Cl3N4O3
• Molecular Weight: 455.72
• Purity: ≥95%
• Target: NF-κB
• Solubility: DMSO: ≥ 46 mg/mL
• Storage: Store at -20C
• IC50: 5.84 uM
• IUPAC Name: 2-chloro-N-[4-[5-(3,4-dichlorophenyl)-3-(2-methoxyethoxy)-1,2,4-triazol-1-yl]phenyl]acetamide
• InChI: InChI=1S/C19H17Cl3N4O3/c1-28-8-9-29-19-24-18(12-2-7-15(21)16(22)10-12)26(25-19)14-5-3-13(4-6-14)23-17(27)11-20/h2-7,10H,8-9,11H2,1H3,(H,23,27)
• InChIKey: TWJGQZBSEMDPQP-UHFFFAOYSA-N
• SMILES: COCCOC1=NN(C(=N1)C2=CC(=C(C=C2)Cl)Cl)C3=CC=C(C=C3)NC(=O)CCl

MI-2(CAT: I000268), also known as MALT1 inhibitor, is a small molecule compound that acts as an irreversible inhibitor of MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1). MALT1 is an important signaling protein involved in the activation of immune responses and the development of certain lymphomas. By inhibiting MALT1, MI-2 disrupts the downstream signaling pathways that promote the growth and survival of cancer cells. MI-2 has demonstrated an IC50 value of 5.84 uM, indicating its potency in inhibiting MALT1 activity.

Reference

1:Short Communication: Preferential Killing of HIV Latently Infected CD4(+) T Cells by MALT1 Inhibitor. Li H, He H, Gong L, Fu M, Wang TT.AIDS Res Hum Retroviruses. 2016 Feb;32(2):174-7. doi: 10.1089/AID.2015.0343. PMID: 26728103 Free PMC Article
2:Antibiotic therapy-induced remission of bladder mucosa-associated lymphoid tissue (MALT) lymphoma carrying t(11;18)(q21;q21) apoptosis inhibitor 2-MALT1. Lucioni M, Nicola M, Riboni R, Croci GA, Rattotti S, Gotti M, Arcaini L, Paulli M, Cristina S, Valentini S, Martinengo C.J Clin Oncol. 2013 Jul 1;31(19):e304-6. doi: 10.1200/JCO.2012.46.4800. Epub 2013 May 20. No abstract available. PMID: 23690413