For research use only. Not for therapeutic Use.
MI-3（Cat No.:I001085）is a selective inhibitor of the protein MDM2, which regulates the tumor suppressor p53. By disrupting the MDM2-p53 interaction, MI-3 reactivates p53 signaling, promoting cell cycle arrest and apoptosis in cancer cells. This compound is particularly relevant in cancers where MDM2 overexpression leads to p53 inactivation, making it a promising candidate for therapeutic intervention. MI-3 has demonstrated efficacy in preclinical models, enhancing p53 activity and showing potential to overcome resistance to conventional therapies. Its mechanism of action positions MI-3 as a valuable tool in developing targeted cancer treatments that restore p53 function.
| Catalog Number | I001085 |
| CAS Number | 1271738-59-0 |
| Synonyms | 4-(4-(5,5-dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-isopropylthieno[2,3-d]pyrimidine |
| Molecular Formula | C₁₈H₂₅N₅S₂ |
| Purity | ≥95% |
| Target | Apoptosis |
| Solubility | in DMSO > 10 mM |
| Storage | Store at -20°C |
| IC50 | 648 ± 25 nM [1] |
| IUPAC Name | 4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-propan-2-ylthieno[2,3-d]pyrimidine |
| InChI | InChI=1S/C18H25N5S2/c1-12(2)14-9-13-15(20-11-21-16(13)24-14)22-5-7-23(8-6-22)17-19-10-18(3,4)25-17/h9,11-12H,5-8,10H2,1-4H3 |
| InChIKey | FUGQNAUKABUDQI-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC2=C(N=CN=C2S1)N3CCN(CC3)C4=NCC(S4)(C)C |
| Reference | </br>1:Fine mapping of the nematode resistance gene Mi-3 in Solanum peruvianum and construction of a S. lycopersicum DNA contig spanning the locus. Yaghoobi J, Yates JL, Williamson VM.Mol Genet Genomics. 2005 Aug;274(1):60-9. Epub 2005 Jul 14. PMID: 16021467 </br>2:Behavior of the [mi-3] mutation and conversion of polymorphic mtDNA markers in heterokaryons of Neurospora crassa. Hawse A, Collins RA, Nargang FE.Genetics. 1990 Sep;126(1):63-72. PMID: 1977658 Free PMC Article</br>3:A missense mutation in the oxi-3 gene of the [mi-3] extranuclear mutant of Neurospora crassa. Lemire EG, Nargang FE.J Biol Chem. 1986 Apr 25;261(12):5610-5. PMID: 3007516 Free Article</br>4:Conversion of a mitochondrial precursor polypeptide into subunit 1 of cytochrome oxidase in the mi-3 mutant of Neurospora crassa. Werner S, Bertrand H.Eur J Biochem. 1979 Sep;99(3):463-70. PMID: 227683 Free Article</br>5:Deficiency of subunit two of cytochrome oxidase in the mi-3 cytoplasmic mutant of Neurospora crassa. Bertrand H, Werner S.Eur J Biochem. 1977 Oct 3;79(2):599-606. No abstract available. PMID: 72665 Free Article</br>6:Comparison of the respiratory chain of Neurospora crassa wild type and the mi-mutants mi-1 and mi-3. von Jagow G, Weiss H, Klingenberg M.Eur J Biochem. 1973 Feb 15;33(1):140-57. No abstract available. PMID: 4144164 Free Article |
