MI-463

• CAT Number: I007981
• CAS Number: 1628317-18-9
• Molecular Formula: C24H23F3N6S
• Molecular Weight: 484.54
• Purity: ≥95%
• Synonyms: MI-463; MI 463; MI463.;4-methyl-5-((4-((6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1H-indole-2-carbonitrile
• Target: Epigenetic Reader Domain
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IC50: 15.3 nM
• IUPAC Name: 4-methyl-5-[[4-[[6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1H-indole-2-carbonitrile
• InChI: InChI=1S/C24H23F3N6S/c1-14-15(2-3-21-19(14)8-17(11-28)31-21)12-33-6-4-16(5-7-33)32-22-20-9-18(10-24(25,26)27)34-23(20)30-13-29-22/h2-3,8-9,13,16,31H,4-7,10,12H2,1H3,(H,29,30,32)
• InChIKey: DZACSLYTXLZAAF-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC2=C1C=C(N2)C#N)CN3CCC(CC3)NC4=C5C=C(SC5=NC=N4)CC(F)(F)F

MI-463（Cat No.:I007981）is a small molecule inhibitor that specifically targets the MDM2-p53 interaction, a key pathway in the regulation of the tumor suppressor protein p53. MDM2 is an E3 ubiquitin ligase that negatively regulates p53 by promoting its degradation. By inhibiting this interaction, MI-463 stabilizes p53, enhancing its tumor-suppressive activity, including the induction of cell cycle arrest and apoptosis in cancer cells. MI-463 is studied for its potential as an anti-cancer agent, particularly in cancers with dysfunctional p53 pathways. It is primarily used in preclinical research and drug development targeting tumor progression.