MI-773

• CAT Number: I001161
• CAS Number: 1303607-07-9
• Molecular Formula: C29H34Cl2FN3O3
• Molecular Weight: 562.50
• Purity: ≥95%
• Synonyms: MI773;MI 773
• Target: Metabolic Enzyme/Protease
• Solubility: 10 mM in DMSO
• Storage: Store at -20℃
• IUPAC Name: (2'R,3S,3'S,5'R)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(4-hydroxycyclohexyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide
• InChI: 1S/C29H34Cl2FN3O3/c1-28(2,3)14-22-29(19-12-7-15(30)13-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-16-8-10-17(36)11-9-16/h4-7,12-13,16-17,22-23,25,35-36H,8-11,14H2,1-3H3,(H,33,37)(H,34,38)/t16?,17?,22-,23+,25-,29+/m1/s1
• InChIKey: IDKAKZRYYDCJDU-YJRDPZTCSA-N
• SMILES: CC(C)(C)C[C@@H]1[C@]2([C@H]([C@@H](N1)C(=O)NC3CCC(CC3)O)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O

MI-773 (Cat No.: I001161) is a selective inhibitor of the MDM2-p53 interaction, a critical pathway that regulates the tumor suppressor p53. By blocking the MDM2 protein, which normally degrades p53, MI-773 stabilizes p53 levels and activates its tumor-suppressive functions, such as inducing cell cycle arrest and apoptosis in cancer cells. This mechanism makes MI-773 a promising candidate for cancer therapy, particularly in tumors where the MDM2-p53 pathway is disrupted. It is being studied for potential use in treating various cancers, including solid tumors and hematologic malignancies.

Reference

[1]. Preparation of spiro-oxindole compounds as MDM2 antagonists. PCT Int. Appl. (2012), WO 2012065022 A2 
[2]. Biomarkers for MDM2 inhibitors for use in treating leukemia. PCT Int. Appl. (2011), WO 2011127058 A2