Mianserin Hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: A000594
  • CAS Number: 21535-47-7
  • Molecular Formula: C18H21ClN2
  • Molecular Weight: 300.83
  • Purity: ≥95%
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Mianserin hydrochloride is a tetracyclic compound with antidepressant effects. It may cause drowsiness and hematological problems. Its mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.


Catalog Number A000594
CAS Number 21535-47-7
Synonyms

21535-47-7; Mianserine hydrochloride; Bolvidon; Athymil; Mianserin HCl

Molecular Formula C18H21ClN2
Purity ≥95%
Target Neuronal Signaling
Solubility >15mg/mL in DMSO
Storage -20°C
InChI 1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
InChIKey YNPFMWCWRVTGKJ-UHFFFAOYSA-N
SMILES CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42.Cl
Reference

1: Sfair LL, Gobetti C, Sangoi Mda S, Lange AD, Steppe M, Schapoval EE. Micellar
electrokinetic chromatographic method for mianserin hydrochloride and analysis of
degradation products by mass spectrometry. Chem Pharm Bull (Tokyo).
2012;60(11):1387-94. PubMed PMID: 23124562.
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2: Sfair LL, Graeff JS, Paim CS, Passos CS, Steppe M, Schapoval EE.
Photodegradation kinetics, cytotoxicity assay and determination by
stability-indicating HPLC method of mianserin hydrochloride. Pharmazie. 2012
Jun;67(6):490-4. PubMed PMID: 22822535.
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3: Chauhan B, Rani S, Guttikar S, Zope A, Jadon N, Padh H. Analytical method
development and validation of mianserin hydrochloride and its metabolite in human
plasma by LC-MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep
5;823(2):69-74. PubMed PMID: 16006201.

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4: Nakamura J, Uchimura N, Yamada S, Nakazawa Y. [Effects of mianserin
hydrochloride on delirium: comparison with the effects of oxypertine and
haloperidol]. Nihon Shinkei Seishin Yakurigaku Zasshi. 1994 Aug;14(4):269-77.
Japanese. PubMed PMID: 7975931.
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5: Marais J. Cochleotoxicity due to Mianserin hydrochloride. J Laryngol Otol.
1991 Jun;105(6):475-6. PubMed PMID: 2072020.
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6: Spinetti G, Battezzati P, Costa R. [Treatment of anxious-depressive syndromes
with Mianserin hydrochloride. Statistical evaluation of the data by Student/’s /t
test/]. Minerva Psichiatr. 1985 Jan-Mar;26(1):79-86. Italian. PubMed PMID:
4021776.
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7: Due&#241;as Laita A, García Roldán JL, González Martínez de Zárate JL,
Velasco-Martín A. Effect of mianserin hydrochloride on oxidative metabolism of
rat brain in vitro. Farmaco Prat. 1983 Jun;38(6):235-42. PubMed PMID: 6309559.

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8: Kamioka T, Sakai Y. [Behavioral pharmacology of mianserin hydrochloride, a new
antidepressant (author/’s transl)]. Nihon Yakurigaku Zasshi. 1980
Sep;76(6):533-47. Japanese. PubMed PMID: 7193623.
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9: Newman B, Crome P. The clinical toxicology of mianserin hydrochloride. Vet Hum
Toxicol. 1979;21 Suppl:60-2. PubMed PMID: 505987.

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10: Coppen A, Gupta R, Montgomery S, Ghose K, Bailey J, Burns B, de Ridder JJ. [A
new antidepressive agent. Mianserin hydrochloride (Tolvin)]. ZFA (Stuttgart).
1978 Oct 31;54(30):1569-73. German. PubMed PMID: 362753.

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