For research use only. Not for therapeutic Use.
Mianserin（Cat No.:I002808）is a tetracyclic antidepressant primarily used in the treatment of major depressive disorder. It works by modulating neurotransmitter systems, particularly by antagonizing receptors for serotonin, histamine, and alpha-adrenergic receptors. This helps to improve mood, reduce anxiety, and promote sleep in patients with depression. Unlike traditional tricyclic antidepressants, mianserin generally has fewer anticholinergic side effects, making it better tolerated in some patients. However, it can still cause drowsiness, weight gain, and sedation. Mianserin is often prescribed when other antidepressants are ineffective or poorly tolerated, though its use is less common today.
| Catalog Number | I002808 |
| CAS Number | 24219-97-4 |
| Synonyms | (R)-3-methyl-1,2,3,4,4a,9-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine |
| Molecular Formula | C18H20N2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20C |
| IUPAC Name | 5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene |
| InChI | InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3 |
| InChIKey | UEQUQVLFIPOEMF-UHFFFAOYSA-N |
| SMILES | CN1CCN2C(C1)C3=CC=CC=C3CC4=CC=CC=C42 |
| Reference | </br>1:Quantum chemical study and isothermal titration calorimetry of β-cyclodextrin complexes with mianserin in aqueous solution. Ignaczak A, Pałecz B, Belica-Pacha S.Org Biomol Chem. 2017 Feb 1;15(5):1209-1216. doi: 10.1039/c6ob02109c. PMID: 28090612 </br>2:Mianserin affects alarm reaction to conspecific chemical alarm cues in Nile tilapia. Barreto RE.Fish Physiol Biochem. 2017 Feb;43(1):193-201. doi: 10.1007/s10695-016-0279-2. Epub 2016 Aug 23. PMID: 27554252 </br>3:Traxoprodil augments the antidepressant-like activity of agomelatine but not of mianserin or tianeptine in the forced swim test in mice. Stasiuk W, Serefko A, Szopa A, Wyska E, Świąder K, Wlaź P, Poleszak E.Pharmacol Rep. 2016 Oct;68(5):960-3. doi: 10.1016/j.pharep.2016.04.013. Epub 2016 May 4. PMID: 27371898 </br>4:The pharmacokinetics of mianserin suppositories for rectal administration in dogs and healthy volunteers: a pilot study. Nawata S, Kohyama N, Uchida N, Numazawa S, Ohbayashi M, Kobayashi Y, Iwata M, Nakajima T, Saito H, Izuka A, Yamamoto T.J Pharm Health Care Sci. 2016 May 17;2:12. doi: 10.1186/s40780-016-0046-7. eCollection 2016. PMID: 27190632 Free PMC Article</br>5:Caffeine augments the antidepressant-like activity of mianserin and agomelatine in forced swim and tail suspension tests in mice. Poleszak E, Szopa A, Wyska E, Kukuła-Koch W, Serefko A, Wośko S, Bogatko K, Wróbel A, Wlaź P.Pharmacol Rep. 2016 Feb;68(1):56-61. doi: 10.1016/j.pharep.2015.06.138. Epub 2015 Jul 17. PMID: 26721352 </br>6:The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine. Roszkowski P, Maurin JK, Czarnocki Z.Beilstein J Org Chem. 2015 Aug 28;11:1509-13. doi: 10.3762/bjoc.11.164. eCollection 2015. PMID: 26425208 Free PMC Article</br>7:[Allosteric effect of serotonin and mianserin on the kinetics of specific [3H]-ligand binding to adrenergic and muscarinic receptors in the rat cerebral cortex membranes]. Manukhin BN, Nesterova LA.Izv Akad Nauk Ser Biol. 2015 Mar-Apr;(2):169-79. Russian. PMID: 26021159 </br>8:Antihyperalgesic and antiallodynic effects of mianserin on diabetic neuropathic pain: a study on mechanism of action. Üçel Uİ, Can ÖD, Demir Özkay Ü, Öztürk Y.Eur J Pharmacol. 2015 Jun 5;756:92-106. doi: 10.1016/j.ejphar.2015.02.048. Epub 2015 Mar 11. PMID: 25771454 </br>9:Evaluation of direct and indirect photodegradation of mianserin with high-performance liquid chromatography and short-term bioassays. Wawryniuk M, Pietrzak A, Nałęcz-Jawecki G.Ecotoxicol Environ Saf. 2015 May;115:144-51. doi: 10.1016/j.ecoenv.2015.02.014. Epub 2015 Feb 18. PMID: 25700092 </br>10:Treatment of vomiting attacks in patients with williams syndrome using mianserin and telazine. Ceylan ME, Yavas E.West Indian Med J. 2014 Mar;63(2):209. doi: 10.7727/wimj.2012.216. Epub 2014 Apr 11. No abstract available. PMID: 25303267 Free PMC Article |
