For research use only. Not for therapeutic Use.
Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin, involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis, leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60, a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex[1].
Miclxin (0-15 μM; 48 h) inhibits the growth of β-catenin-mutated HCT116 cells and isogenic HCT116 (CTNNB1 Δ45/-) cells, and induces (10 μM; 24 h) apoptosis in HCT116 cells[1].
| Catalog Number | I041789 |
| CAS Number | 2494198-61-5 |
| Synonyms | 7-methoxy-N-[(3-methoxyphenyl)methyl]-2-(3-pyridin-3-ylpyrrolidin-1-yl)quinazolin-4-amine |
| Molecular Formula | C26H27N5O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H27N5O2/c1-32-21-7-3-5-18(13-21)15-28-25-23-9-8-22(33-2)14-24(23)29-26(30-25)31-12-10-20(17-31)19-6-4-11-27-16-19/h3-9,11,13-14,16,20H,10,12,15,17H2,1-2H3,(H,28,29,30) |
| InChIKey | OXSWPFXQCLRTCF-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)C(=NC(=N2)N3CCC(C3)C4=CN=CC=C4)NCC5=CC(=CC=C5)OC |
| Reference | [1]. Ikeda H, et al. Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells. ACS Chem Biol. 2020 Aug 21;15(8):2195-2204. |
