For research use only. Not for therapeutic Use.
Miconazole Nitrate（Cat No.:A000397）is an antifungal agent commonly used to treat a variety of fungal infections, including athlete’s foot, ringworm, and yeast infections. It works by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, leading to membrane disruption and cell death. Available in topical formulations, Miconazole Nitrate is effective against both dermatophytes and yeast pathogens. Its broad-spectrum activity makes it a preferred treatment for localized skin infections. Additionally, it is also used in oral forms for treating fungal infections in the mouth and throat.
| Catalog Number | A000397 |
| CAS Number | 22832-87-7 |
| Synonyms | NSC 169434 Nitrate |
| Molecular Formula | C18H14Cl4N2O • HNO3 |
| Purity | ≥95% |
| Target | Fungal |
| Storage | 3 years -20C powder |
| IUPAC Name | 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid |
| InChI | InChI=1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4) |
| InChIKey | MCCACAIVAXEFAL-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-] |
| Reference | <p>Rice L.B. and Ghannoum M.A.. /Antifungal Agents: Mode of Action, Mechanisms of Resistance, and Correlation of These Mechanisms with Bacterial Resistance. Clinical Microbiology Reviews (1999): 501-17.</p><p>Sreedhara, K. H. /Studies on the Mechanism of Action of Miconazole: Effect of Miconazole on Respiration and Cell Permeability of Candida Albicans./ <em>Antimicrobial Agents and Chemotherapy</em> 5.4 (1974): 420-25. <em>w ww.ncbi.gov.</em> American Society for Microbiology. Web. 22 Aug. 2012.</p></span></p> |
