Micrococcin P1

• CAT Number: R007199
• CAS Number: 67401-56-3
• Molecular Formula: C48H49N13O9S6
• Molecular Weight: 1144.40
• Purity: ≥95%
• Synonyms: 2’-[(11S,14Z,21S,28S)-14-ethylidene-9,10,11,12,13,14,20,21,27,28-decahydro-28-[(1R)-1-hydroxyethyl]-11-[(1R)-1-hydroxyethyl]-21-(1-methylethyl)-9,12,19,26-tetraoxo-19H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]t
• Target: Bacterial
• Storage: -20°C
• IUPAC Name: 2-[2-[(26E)-26-ethylidene-12,29-bis(1-hydroxyethyl)-14,21,28,31-tetraoxo-19-propan-2-yl-10,17,24,34-tetrathia-6,13,20,27,30,35,36,37,38-nonazahexacyclo[30.2.1.18,11.115,18.122,25.02,7]octatriaconta-1(35),2(7),3,5,8,11(38),15,18(37),22,25(36),32-undecaen-5-yl]-1,3-thiazol-4-yl]-N-[(E)-1-(2-hydroxypropylamino)-1-oxobut-2-en-2-yl]-1,3-thiazole-4-carboxamide
• InChI: InChI=1S/C48H49N13O9S6/c1-8-24(37(65)49-12-20(5)62)51-38(66)28-15-73-46(56-28)32-18-74-45(58-32)26-11-10-23-36(50-26)27-13-75-48(53-27)35(22(7)64)61-41(69)31-17-76-47(57-31)33(19(3)4)59-39(67)30-16-72-44(55-30)25(9-2)52-42(70)34(21(6)63)60-40(68)29-14-71-43(23)54-29/h8-11,13-22,33-35,62-64H,12H2,1-7H3,(H,49,65)(H,51,66)(H,52,70)(H,59,67)(H,60,68)(H,61,69)/b24-8+,25-9+
• InChIKey: MQGFYNRGFWXAKA-IQEGOQEASA-N
• SMILES: C/C=C/1\C2=NC(=CS2)C(=O)NC(C3=NC(=CS3)C(=O)NC(C4=NC(=CS4)C5=C(C=CC(=N5)C6=NC(=CS6)C7=NC(=CS7)C(=O)N/C(=C/C)/C(=O)NCC(C)O)C8=NC(=CS8)C(=O)NC(C(=O)N1)C(C)O)C(C)O)C(C)C

Micrococcin P1（Cat No.:R007199）is a potent antimicrobial peptide isolated from Micrococcus luteus. It exhibits broad-spectrum antibacterial activity, particularly against Gram-positive bacteria. Micrococcin P1 functions by inhibiting protein synthesis, binding to bacterial ribosomes, and preventing the elongation of polypeptides. This mechanism of action makes it a promising candidate for the development of novel antibiotics, especially in combating antibiotic-resistant bacteria. Its stability and selective toxicity toward bacteria, rather than mammalian cells, further enhance its potential for therapeutic applications. Ongoing research explores its application in various pharmaceutical formulations.

Reference

Antibiotic-producing organisms in faeces and sewage. Su T.L. Brit. J. Exp. Path. 1948, 29, 466.The preparation and some properties of purified micrococcin. Heatley N.G. and Doery H.M. Biochem. J. 1951, 50, 247. Micrococcin P1: Structure, biology and synthesis. Ciufolini M.A. and Lefranc D. Nat. Prod. Reports 2010, 27, 330. Isolation of three new antibiotics, thiocillins I, II and III, related to micrococcin. P. Shoji J. J. Antibiot. 1976, 29, 366.