microRNA-21-IN-3

• CAT Number: I041151
• CAS Number: 2766106-83-4
• Molecular Formula: C16H17N7O
• Molecular Weight: 323.35
• Purity: ≥95%
• Synonyms: 2-[(5-piperazin-1-ylpyridin-2-yl)amino]-3H-pyrido[3,4-d]pyrimidin-4-one
• InChI: InChI=1S/C16H17N7O/c24-15-12-3-4-18-10-13(12)20-16(22-15)21-14-2-1-11(9-19-14)23-7-5-17-6-8-23/h1-4,9-10,17H,5-8H2,(H2,19,20,21,22,24)
• InChIKey: DLSJIJCYLWIPFC-UHFFFAOYSA-N
• SMILES: C1CN(CCN1)C2=CN=C(C=C2)NC3=NC4=C(C=CN=C4)C(=O)N3

microRNA-21-IN-3 (compound 45) can specifically bind to the precursor of oncogenic and pro-inflammatory microRNA-21 with medium nanomolar affinity, reduce cancer cell proliferation and miR-21 levels, and can be used in antitumor research[1].

Reference

[1]. Matthew D Shortridge, et al. Drug-Like Small Molecules That Inhibit Expression of the Oncogenic MicroRNA-21. ACS Chem Biol. 2023 Feb 17;18(2):237-250. 
 [Content Brief]