Midecamycin

• CAT Number: I003292
• CAS Number: 35457-80-8
• Molecular Formula: C41H67NO15
• Molecular Weight: 813.97
• Purity: ≥95%
• Target: Antibacterial
• Solubility: DMSO: ≥ 35 mg/mL
• Storage: 3 years -20℃ powder
• IUPAC Name: [(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)-4-(dimethylamino)-3-hydroxy-5-[(2S,4R,5S,6S)-4-hydroxy-4,6-dimethyl-5-propanoyloxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl] propanoate
• InChI: InChI=1S/C41H67NO15/c1-11-30(45)54-29-21-32(47)51-24(4)16-14-13-15-17-28(44)23(3)20-27(18-19-43)37(38(29)50-10)57-40-35(48)34(42(8)9)36(25(5)53-40)56-33-22-41(7,49)39(26(6)52-33)55-31(46)12-2/h13-15,17,19,23-29,33-40,44,48-49H,11-12,16,18,20-22H2,1-10H3/b14-13+,17-15+/t23-,24-,25-,26+,27+,28+,29-,33+,34-,35-,36-,37+,38+,39+,40+,41-/m1/s1
• InChIKey: DMUAPQTXSSNEDD-QALJCMCCSA-N
• SMILES: CCC(=O)O[C@@H]1CC(=O)O[C@@H](C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]1OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)OC(=O)CC)(C)O)N(C)C)O)CC=O)C)O)C

Midecamycin（Cat No.:I003292）is a macrolide antibiotic derived from Streptomyces mycarofaciens, effective against various Gram-positive bacteria and some Gram-negative organisms. It works by binding to the 50S ribosomal subunit, inhibiting protein synthesis and bacterial growth. Primarily used to treat respiratory and skin infections, midecamycin is known for its effectiveness against pathogens like Streptococcus pneumoniae and Staphylococcus aureus. Its relatively mild side effect profile and high tissue penetration make it a preferred choice in managing mild to moderate infections, particularly for patients allergic to penicillins. Midecamycin remains a valuable option in antimicrobial therapy.

Reference

[1]. Neu HC. In vitro activity of midecamycin, a new macrolide antibiotic. Antimicrob Agents Chemother. 1983 Sep;24(3):443-4.

[2]. Cong L, et al. Cloning and characterization of genes encoded in dTDP-D-mycaminose biosynthetic pathway from amidecamycin-producing strain, Streptomyces mycarofaciens. Acta Biochim Biophys Sin (Shanghai). 2007 Mar;39(3):187-93.