Midesteine

• CAT Number: I032271
• CAS Number: 94149-41-4
• Molecular Formula: C12H13NO3S3
• Molecular Weight: 315.42
• Purity: 98%
• Synonyms: Midesteine; MR 889; MR889; MR-889.
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 2-Thiophenecarbothioic acid, S-(1-methyl-2-oxo-2-((tetrahydro-2-oxo-3-thienyl)amino)ethyl) ester
• InChI: InChI=1S/C12H13NO3S3/c1-7(16-12(17)9-3-2-5-18-9)10(14)13-8-4-6-19-11(8)15/h2-3,5,7-8H,4,6H2,1H3,(H,13,14)/t7?,8-/m0/s1
• InChIKey: RZSPDIRWSJHFTB-MQWKRIRWSA-N
• SMILES: S=C(C1=CC=CS1)OC(C)C(N[C@@H](CCS2)C2=O)=O

Midesteine is a cyclic thiolic neutrophil elastase inhibitor.

Reference

1: Luisetti M, Piccioni PD, Donnini M, Peona V, Pozzi E, Grassi C. Studies of MR 889, a new synthetic proteinase inhibitor. Biochem Biophys Res Commun. 1989 Dec 15;165(2):568-73. PubMed PMID: 2597145.
2: Luisetti M, Piccioni PD, Donnini M, Alesina R, Donnetta AM, Peona V. On the activity of MR 889, a new synthetic proteinase inhibitor. Ann N Y Acad Sci. 1991;624:343-4. PubMed PMID: 1712157.
3: Gentili P, Pelloso R, La Rosa C, Galzigna L, Lucarelli C. Absorption, distribution, metabolism and excretion of 2-[2-thiophenecarboxythio]-N-[dihydro-2-(3H)-thiophenone-3-yl]-propiona mide in the rat. Arzneimittelforschung. 1990 Nov;40(11):1214-7. PubMed PMID: 2085332.
4: Luisetti M, Sturani C, Sella D, Madonini E, Galavotti V, Bruno G, Peona V, Kucich U, Dagnino G, Rosenbloom J, Starcher B, Grassi C. MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial. Eur Respir J. 1996 Jul;9(7):1482-6. PubMed PMID: 8836663.
5: Ohbayashi H. Neutrophil elastase inhibitors as treatment for COPD. Expert Opin Investig Drugs. 2002 Jul;11(7):965-80. Review. PubMed PMID: 12084007.
6: Baici A, Pelloso R, Hörler D. The kinetic mechanism of inhibition of human leukocyte elastase by MR889, a new cyclic thiolic compound. Biochem Pharmacol. 1990 Mar 1;39(5):919-24. PubMed PMID: 2310417.
7: Moretti M, Gorrini M, Donnetta AM, Baldini EV, Venturini R, Marchioni CF, Iadarola P, Luisetti M. Effects of MR889, a cyclic thiolic neutrophil elastase inhibitor, on rheologic properties of mucus. Life Sci. 1994;54(7):463-9. PubMed PMID: 8309349.