MIF-Antagonist, ISO-1

For research use only. Not for therapeutic Use.

  • CAT Number: I003675
  • CAS Number: 478336-92-4
  • Molecular Formula: C₁₂H₁₃NO₄
  • Molecular Weight: 235.24
  • Purity: ≥95%
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ISO-1(CAT: I003675) operates as an antagonist of macrophage migration inhibitory factor (MIF). This compound specifically targets MIF, an important regulatory protein. In vitro, studies demonstrate that ISO-1 hinders MIF tautomerase activity in a dose-dependent manner, with the hydroxylated phenyl analog being less potent. ISO-1’s potential mechanism includes the modulation of arachidonic acid release, while its application curtails cytokine activity and tumor necrosis factor release from macrophages. In vivo, ISO-1 administration showcases promising outcomes, leading to reduced implant size and vascularity, potentially influencing therapeutic strategies involving MIF-related processes and responses.


Catalog Number I003675
CAS Number 478336-92-4
Synonyms

ISO-1;Macrophage Migration Inhibitory Factor

Molecular Formula C₁₂H₁₃NO₄
Purity ≥95%
Target Macrophage migration inhibitory factor (MIF)
Solubility DMSO: ≥ 36 mg/mL
Storage -20°C
IC50 7 uM [1]
InChI InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,13H,6-7H2,1H3
InChIKey CLVQGFPQFNASJH-UHFFFAOYSA-N
SMILES COC(=O)CC1CC(=C2C=CC(=O)C=C2)NO1
Reference

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<br>[1]. Lubetsky JB, et al. The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents. J Biol Chem. 2002 Jul 12;277(28):24976-82.
<br>[2]. Al-Abed Y, et al. ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis. J Biol Chem. 2005 Nov 4;280(44):36541-4.
<br>[3]. Nothnick WB, et al. Inhibition of macrophage migration inhibitory factor reduces endometriotic implant size in mice with experimentally induced disease. J Endometr. 2011 Sep 30;3(3):135-142.
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