For research use only. Not for therapeutic Use.
ISO-1(CAT: I003675) operates as an antagonist of macrophage migration inhibitory factor (MIF). This compound specifically targets MIF, an important regulatory protein. In vitro, studies demonstrate that ISO-1 hinders MIF tautomerase activity in a dose-dependent manner, with the hydroxylated phenyl analog being less potent. ISO-1’s potential mechanism includes the modulation of arachidonic acid release, while its application curtails cytokine activity and tumor necrosis factor release from macrophages. In vivo, ISO-1 administration showcases promising outcomes, leading to reduced implant size and vascularity, potentially influencing therapeutic strategies involving MIF-related processes and responses.
Catalog Number | I003675 |
CAS Number | 478336-92-4 |
Synonyms | ISO-1;Macrophage Migration Inhibitory Factor |
Molecular Formula | C₁₂H₁₃NO₄ |
Purity | ≥95% |
Target | Macrophage migration inhibitory factor (MIF) |
Solubility | DMSO: ≥ 36 mg/mL |
Storage | -20°C |
IC50 | 7 uM [1] |
InChI | InChI=1S/C12H13NO4/c1-16-12(15)7-10-6-11(13-17-10)8-2-4-9(14)5-3-8/h2-5,10,13H,6-7H2,1H3 |
InChIKey | CLVQGFPQFNASJH-UHFFFAOYSA-N |
SMILES | COC(=O)CC1CC(=C2C=CC(=O)C=C2)NO1 |
Reference | <p style=/line-height:25px/> |