MIF098

• CAT Number: I043367
• CAS Number: 1208448-95-6
• Molecular Formula: C15H13NO3
• Molecular Weight: 255.27
• Purity: ≥95%
• Synonyms: 3-[(3-hydroxyphenyl)methyl]-5-methyl-1,3-benzoxazol-2-one
• InChI: InChI=1S/C15H13NO3/c1-10-5-6-14-13(7-10)16(15(18)19-14)9-11-3-2-4-12(17)8-11/h2-8,17H,9H2,1H3
• InChIKey: JJXKGUBHEQGADG-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C=C1)OC(=O)N2CC3=CC(=CC=C3)O

MIF098 is a macrophage migration inhibitory factor (MIF) antagonist. MIF098 inhibits proliferation, migration and fibrosis of pulmonary smooth muscle cells. MIF098 can be used for immunoinflammation-related disease research[1].
MIF098 (0-10 μM, 48 h) inhibits mPASMC cell proliferation and migration in a concentration-dependent manner, by blocking the migration inhibitory factor (MIF) pathway[1].
MIF098 reduces collagen synthesis and pulmonary artery fibrosis by inhibiting the TGFβ1/Smad2/3 pathway[1].
MIF098 (intraperitoneal injection, 40 mg/kg, once a day, 4 weeks) attenuates the process of hypoxia-induced pulmonary arterial hypertension in C57BL/6J mice[1].

Reference

[1]. HuijingHuang, et al. The small molecule macrophage migration inhibitory factor antagonist MIF098, inhibits pulmonary hypertension associated with murine SLE. Int Immunopharmacol. 2019 Nov;76:105874.
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