For research use only. Not for therapeutic Use.
Milademetan (CAT: I012065) is a potent and selective inhibitor of MDM2, a protein that negatively regulates the tumor suppressor protein p53. By inhibiting the interaction between MDM2 and p53, milademetan promotes p53 activation and stabilization, leading to cell cycle arrest, apoptosis, and inhibition of tumor growth. Milademetan has demonstrated efficacy in preclinical models and is being investigated as a potential treatment for various p53 wild-type solid tumors and hematological malignancies. Clinical trials are underway to evaluate the safety and efficacy of milademetan as a targeted therapy for cancer.
| Catalog Number | I012065 |
| CAS Number | 1398568-47-2 |
| Synonyms | Milademetan; DS-3032; DS3032; DS 3032 |
| Molecular Formula | C30H34Cl2FN5O4 |
| Purity | ≥95% |
| Target | MDM-2/p53; E1/E2/E3 Enzyme; Apoptosis |
| Storage | Room temperature |
| InChI | InChI=1S/C30H34Cl2FN5O4/c1-28(2)8-10-29(11-9-28)30(18-5-3-15(31)13-19(18)37-27(30)41)21(17-7-12-35-24(32)22(17)33)23(38-29)26(40)36-16-4-6-20(25(34)39)42-14-16/h3,5,7,12-13,16,20-21,23,38H,4,6,8-11,14H2,1-2H3,(H2,34,39)(H,36,40)(H,37,41)/t16-,20+,21+,23-,30-/m1/s1 |
| InChIKey | RYAYYVTWKAOAJF-QISPRATLSA-N |
| SMILES | CC1(CCC2(CC1)C3(C(C(N2)C(=O)NC4CCC(OC4)C(=O)N)C5=C(C(=NC=C5)Cl)F)C6=C(C=C(C=C6)Cl)NC3=O)C |
