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37065-29-5-Miloxacin Miloxacin

Miloxacin

For research use only. Not for therapeutic Use.

  • CAT Number: I032291
  • CAS Number: 37065-29-5
  • Molecular Formula: C12H9NO6
  • Molecular Weight: 263.21
  • Purity: 98%
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Related Small Molecules: H3K27(Me3) (15-34)     Pipotiazine     Cefpiramide sodium    

Miloxacin (Cat.No:I032291) is an antibiotic active against gram-negative bacteria. It also exhibits chemotherapeutic properties comparable to those of oxolinic acid and nalidixic acid.


Catalog Number I032291
CAS Number 37065-29-5
Synonyms

Miloxacin; AB 206; AB-206; AB206

Molecular Formula C12H9NO6
Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 1,3-Dioxolo(4,5-g)quinoline-7-carboxylic acid, 5,8-dihydro-5-methoxy-8-oxo-
InChI InChI=1S/C12H9NO6/c1-17-13-4-7(12(15)16)11(14)6-2-9-10(3-8(6)13)19-5-18-9/h2-4H,5H2,1H3,(H,15,16)
InChIKey ABQYZRZVRIPTPI-UHFFFAOYSA-N
SMILES O=C(C1=CN(OC)C2=CC(OCO3)=C3C=C2C1=O)O
Reference

1: Izawa A, Kisaki Y, Irie K, Eda Y, Nakagome T, Komatsu T. Antibacterial activity of miloxacin. Antimicrob Agents Chemother. 1980 Jul;18(1):37-40. PubMed PMID: 7416749; PubMed Central PMCID: PMC283935.
2: Yoshitake A, Kawahara K, Izawa A, Shono F. [Absorption, distribution, excretion, and metabolism of 14C-miloxacin in female rats (author’s transl)]. Radioisotopes. 1980 Aug;29(8):377-81. Japanese. PubMed PMID: 7208993.
3: Izawa A, Yoshitake A, Komatsu T. Absorption and excretion of miloxacin in mice, rats, and dogs. Antimicrob Agents Chemother. 1980 Jul;18(1):41-4. PubMed PMID: 7416750; PubMed Central PMCID: PMC283936.
4: Yoshitake A, Kawahara K, Shono F, Umeda I, Izawa A, Komatsu T. Determination of miloxacin and metabolites in human serum and urine by high-pressure liquid chromatography. Antimicrob Agents Chemother. 1980 Jul;18(1):45-9. PubMed PMID: 7416751; PubMed Central PMCID: PMC283937.
5: Yoshitake A, Kawahara K, Shono F. [Metabolism of 14C-miloxacin in rats–metabolites in urine, bile and feces (author’s transl)]. Radioisotopes. 1979 Nov;28(11):687-91. Japanese. PubMed PMID: 531250.
6: Ueno R, Aoki T. High-performance liquid chromatographic method for the rapid and simultaneous determination of sulfamonomethoxine, miloxacin and oxolinic acid in serum and muscle of cultured fish. J Chromatogr B Biomed Appl. 1996 Jun 28;682(1):179-81. PubMed PMID: 8832440.
7: Srinivas NR. Interspecies scaling of excretory amounts using allometry – retrospective analysis with rifapentine, aztreonam, carumonam, pefloxacin, miloxacin, trovafloxacin, doripenem, imipenem, cefozopran, ceftazidime, linezolid for urinary excretion and rifapentine, cabotegravir, and dolutegravir for fecal excretion. Xenobiotica. 2016 Sep;46(9):784-92. doi: 10.3109/00498254.2015.1121554. Epub 2015 Dec 29. PubMed PMID: 26711252.
8: Nakano M, Kanzaki R, Hayakawa M, Adachi M, Kawai M, Imadaka K, Takizuka H, Okayama K, Katsu M, Nose N, Notoya T, Takeda N. [Clinical studies of miloxacin for acute intestinitis (author’s transl)]. Kansenshogaku Zasshi. 1981 Nov;55(11):819-25. Japanese. PubMed PMID: 6801153.
9: [Chemotherapy on the biliary tract infections. XIII. Miloxacin, a novel chemotherapeutic agent, its excretion into bile and clinical effect on the biliary tract infections (author’s transl)]. Jpn J Antibiot. 1981 Sep;34(9):1335-52. Japanese. PubMed PMID: 7328756.
10: Igari J, Kosakai N, Oguri T. [Antimicrobial susceptibility patterns of clinical isolates of Pseudomonas cepacia (author’s transl)]. Jpn J Antibiot. 1979 Oct;32(10):998-1002. Japanese. PubMed PMID: 259663.
11: Okezaki E, Terasaki T, Nakamura M, Nagata O, Kato H, Tsuji A. Structure-tissue distribution relationship based on physiological pharmacokinetics for NY-198, a new antimicrobial agent, and the related pyridonecarboxylic acids. Drug Metab Dispos. 1988 Nov-Dec;16(6):865-74. PubMed PMID: 2907467.
12: Nagate T, Kurashige S, Mitsuhashi S. In vitro and in vivo antibacterial activity of AB206, a new naphthyridine derivative. Antimicrob Agents Chemother. 1980 Feb;17(2):203-8. PubMed PMID: 7387143; PubMed Central PMCID: PMC283759.
13: Ohno I, Ida S. [Refractory respiratory tract infections. 7. Trends in the development of new chemotherapeutic agents for respiratory tract infections. b. Synthetic antibacterial agents]. Nihon Rinsho. 1987 Mar;45(3):577-82. Review. Japanese. PubMed PMID: 3298736.
14: Nagate T, Komatsu T, Izawa A, Ohmura S, Namiki S, Mitsuhashi S. Mode of action of a new nalidixic acid derivative, AB206. Antimicrob Agents Chemother. 1980 May;17(5):763-9. PubMed PMID: 6156644; PubMed Central PMCID: PMC283872.
15: Umeda I, Anzai H, Murano A. [Determination of a new antibacterial agent miloxacin by high performance liquid chromatography and ultraviolet spectrophotometry (author’s transl)]. Yakugaku Zasshi. 1979 Jul;99(7):770-4. Japanese. PubMed PMID: 544795.

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