For research use only. Not for therapeutic Use.
Milvexian（Cat No.:I032295）is an oral, small-molecule inhibitor of activated Factor XI (FXIa), developed as a novel anticoagulant for the prevention and treatment of thromboembolic disorders. Unlike traditional anticoagulants, Milvexian targets FXIa, a key enzyme in the intrinsic coagulation pathway, aiming to reduce clot formation while minimizing bleeding risk. Clinical trials have demonstrated its efficacy in preventing venous thromboembolism and stroke with a favorable safety profile. Milvexian represents a new class of anticoagulants offering targeted therapy with improved bleeding safety, making it a promising option for long-term anticoagulation management.
| CAS Number | 1802425-99-5 |
| Synonyms | (9R,13S)-13-[4-[5-chloro-2-(4-chlorotriazol-1-yl)phenyl]-6-oxopyrimidin-1-yl]-3-(difluoromethyl)-9-methyl-3,4,7,15-tetrazatricyclo[12.3.1.02,6]octadeca-1(18),2(6),4,14,16-pentaen-8-one |
| Molecular Formula | C28H23Cl2F2N9O2 |
| Purity | ≥95% |
| IUPAC Name | (9R,13S)-13-[4-[5-chloro-2-(4-chlorotriazol-1-yl)phenyl]-6-oxopyrimidin-1-yl]-3-(difluoromethyl)-9-methyl-3,4,7,15-tetrazatricyclo[12.3.1.02,6]octadeca-1(18),2(6),4,14,16-pentaen-8-one |
| InChI | InChI=1S/C28H23Cl2F2N9O2/c1-15-3-2-4-23(20-9-16(7-8-33-20)26-21(36-27(15)43)12-35-41(26)28(31)32)39-14-34-19(11-25(39)42)18-10-17(29)5-6-22(18)40-13-24(30)37-38-40/h5-15,23,28H,2-4H2,1H3,(H,36,43)/t15-,23+/m1/s1 |
| InChIKey | FSWFYCYPTDLKON-CMJOXMDJSA-N |
| SMILES | C[C@@H]1CCC[C@@H](C2=NC=CC(=C2)C3=C(C=NN3C(F)F)NC1=O)N4C=NC(=CC4=O)C5=C(C=CC(=C5)Cl)N6C=C(N=N6)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
