For research use only. Not for therapeutic Use.
Minaprine (Cat No.: I002880) is a psychotropic drug with antidepressant and nootropic properties, acting as a reversible monoamine oxidase A (MAO-A) inhibitor and a serotonin (5-HT2A) receptor antagonist. It enhances neurotransmitter activity by increasing serotonin, dopamine, and noradrenaline levels, contributing to its antidepressant effects. Minaprine has been studied for cognitive enhancement and neuroprotection, showing potential in neurodegenerative disorders. Although once used for depression treatment, its clinical use has declined due to adverse effects. It remains of interest in neuroscience research.
| CAS Number | 25905-77-5 |
| Molecular Formula | C17H22N4O |
| Purity | ≥95% |
| Target | Monoamine Oxidase |
| Solubility | DMSO: ≥ 35 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine |
| InChI | 1S/C17H22N4O/c1-14-13-16(15-5-3-2-4-6-15)19-20-17(14)18-7-8-21-9-11-22-12-10-21/h2-6,13H,7-12H2,1H3,(H,18,20) |
| InChIKey | LDMWSLGGVTVJPG-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NN=C1NCCN2CCOCC2)C3=CC=CC=C3 |
| Reference | </br>1:Double-blind comparative study of the antidepressant, unwanted and cardiac effects of minaprine and amitriptyline. Edwards JG, Dinan TG, Waller DG, Greentree SG.Br J Clin Pharmacol. 1996 Oct;42(4):491-8. PMID: 8904622 Free PMC Article</br>2:[Evaluation by poison control centers of minaprine from the modification of tablet dosages]. Jouglard J, Perringue C, Goujard J, Servetti A, David JM.Therapie. 1996 Sep-Oct;51(5):582-5. French. PMID: 9138401 </br>3:[Randomized double-blind comparative study of minaprine (200mg/j) and of placebo on memory loss]. Allain H, Belliard S, Lieury A, Menard G, Patat A, Le Coz F, Gandon JM.Therapie. 1996 Mar-Apr;51(2):155-62. French. PMID: 8763050 </br>4:A comparison of the behavioral effects of minaprine, amphetamine and stress. Cabib S, Zocchi A, Puglisi-Allegra S.Psychopharmacology (Berl). 1995 Sep;121(1):73-80. PMID: 8539343 </br>5:Prevention by minaprine of ischemic neuronal damage and memory impairment in Mongolian gerbils. Piao Y, Mineshita S, Kuroiwa T, Koike Y.Nihon Shinkei Seishin Yakurigaku Zasshi. 1995 Apr;15(2):157-63. PMID: 7796320 </br>6:Multicentric double-blind study comparing efficacy and safety of minaprine and imipramine in dysthymic disorders. Salzmann E, Robin JL.Neuropsychobiology. 1995;31(2):68-75. PMID: 7760988 </br>7:Minaprine, but not oxiracetam, prevents desipramine-induced impairment of avoidance learning in mice. Sansone M, Battaglia M, Vetulani J.Pol J Pharmacol. 1995 Jan-Feb;47(1):69-73. PMID: 7550552 </br>8:Effects of subchronic minaprine on dopamine release in the ventral striatum and on immobility in the forced swimming test. Imperato A, Obinu MC, Cabib S, Cestari V, Puglisi-Allegra S.Neurosci Lett. 1994 Jan 17;166(1):69-72. PMID: 8190361 </br>9:Involvement of protein kinase C activation in regulation of acetylcholine release from rat hippocampal slices by minaprine. Chaki S, Muramatsu M, Otomo S.Neurochem Int. 1994 Jan;24(1):37-41. PMID: 8130734 </br>10:Post-training minaprine enhances memory storage in mice: involvement of D1 and D2 dopamine receptors. Puglisi-Allegra S, Cabib S, Cestari V, Castellano C.Psychopharmacology (Berl). 1994 Jan;113(3-4):476-80. PMID: 7862862 |
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